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PubMed:7706235 JSONTXT 29 Projects

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Id Subject Object Predicate Lexical cue
T1 0-62 Sentence denotes Nitric oxide-stimulated guanine nucleotide exchange on p21ras.
T1 0-62 Sentence denotes Nitric oxide-stimulated guanine nucleotide exchange on p21ras.
T2 63-222 Sentence denotes The protooncogene p21ras, a monomeric G protein family member, plays a critical role in converting extracellular signals into intracellular biochemical events.
T2 63-222 Sentence denotes The protooncogene p21ras, a monomeric G protein family member, plays a critical role in converting extracellular signals into intracellular biochemical events.
T3 223-344 Sentence denotes Here, we report that nitric oxide (NO) activates p21ras in human T cells as evidenced by an increase in GTP-bound p21ras.
T3 223-344 Sentence denotes Here, we report that nitric oxide (NO) activates p21ras in human T cells as evidenced by an increase in GTP-bound p21ras.
T4 345-449 Sentence denotes In vitro studies using pure recombinant p21ras demonstrate that the activation is direct and reversible.
T4 345-449 Sentence denotes In vitro studies using pure recombinant p21ras demonstrate that the activation is direct and reversible.
T5 450-582 Sentence denotes Circular dichroism analysis reveals that NO induces a profound conformational change in p21ras in association with GDP/GTP exchange.
T5 450-582 Sentence denotes Circular dichroism analysis reveals that NO induces a profound conformational change in p21ras in association with GDP/GTP exchange.
T6 583-713 Sentence denotes The mechanism of activation is due to S-nitrosylation of a critical cysteine residue which stimulates guanine nucleotide exchange.
T6 583-713 Sentence denotes The mechanism of activation is due to S-nitrosylation of a critical cysteine residue which stimulates guanine nucleotide exchange.
T7 714-895 Sentence denotes Furthermore, we demonstrate that p21ras is essential for NO-induced downstream signaling, such as NF-kappa B activation, and that endogenous NO can activate p21ras in the same cell.
T7 714-895 Sentence denotes Furthermore, we demonstrate that p21ras is essential for NO-induced downstream signaling, such as NF-kappa B activation, and that endogenous NO can activate p21ras in the same cell.
T8 896-955 Sentence denotes These studies identify p21ras as a target of the same cell.
T8 896-955 Sentence denotes These studies identify p21ras as a target of the same cell.
T9 956-1122 Sentence denotes These studies identify p21ras as a target of NO in T cells and suggest that NO activates p21ras by an action which mimics that of guanine nucleotide exchange factors.
T9 956-1122 Sentence denotes These studies identify p21ras as a target of NO in T cells and suggest that NO activates p21ras by an action which mimics that of guanine nucleotide exchange factors.