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Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-109 Sentence denotes Glycoprotein 330, a member of the low density lipoprotein receptor family, binds lipoprotein lipase in vitro.
T1 0-109 Sentence denotes Glycoprotein 330, a member of the low density lipoprotein receptor family, binds lipoprotein lipase in vitro.
T2 110-344 Sentence denotes Glycoprotein 330 (gp330), a cell-surface protein that is localized in clathrin-coated pits, is structurally related to both the low density lipoprotein receptor (LDLR) and the LDLR-related protein/alpha 2-macroglobulin receptor (LRP).
T2 110-344 Sentence denotes Glycoprotein 330 (gp330), a cell-surface protein that is localized in clathrin-coated pits, is structurally related to both the low density lipoprotein receptor (LDLR) and the LDLR-related protein/alpha 2-macroglobulin receptor (LRP).
T3 345-514 Sentence denotes We recently demonstrated that gp330 and LRP may be functionally related as well; both bind the 39-kDa polypeptide referred to as receptor-associated protein (Kounnas, M.
T3 345-514 Sentence denotes We recently demonstrated that gp330 and LRP may be functionally related as well; both bind the 39-kDa polypeptide referred to as receptor-associated protein (Kounnas, M.
T4 515-531 Sentence denotes Z., Argraves, W.
T4 515-531 Sentence denotes Z., Argraves, W.
T5 532-554 Sentence denotes S., and Strickland, D.
T5 532-554 Sentence denotes S., and Strickland, D.
T6 555-567 Sentence denotes K. (1992) J.
T6 555-567 Sentence denotes K. (1992) J.
T7 568-573 Sentence denotes Biol.
T7 568-573 Sentence denotes Biol.
T8 574-579 Sentence denotes Chem.
T8 574-579 Sentence denotes Chem.
T9 580-598 Sentence denotes 267, 21162-21166).
T9 580-598 Sentence denotes 267, 21162-21166).
T10 599-715 Sentence denotes In this report, we tested several other LRP ligands for their ability to interact with human and rat gp330 in vitro.
T10 599-715 Sentence denotes In this report, we tested several other LRP ligands for their ability to interact with human and rat gp330 in vitro.
T11 716-853 Sentence denotes Gp330 did not exhibit detectable binding to the LRP ligands, alpha 2-macroglobulin protease complex or Pseudomonas aeruginosa exotoxin A.
T11 716-853 Sentence denotes Gp330 did not exhibit detectable binding to the LRP ligands, alpha 2-macroglobulin protease complex or Pseudomonas aeruginosa exotoxin A.
T12 854-1019 Sentence denotes However, we found that gp330 (purified from human or rat) bound the lipolytic enzyme lipoprotein lipase (LPL) with high affinity (Kd = 6.1 and 2.7 nM, respectively).
T12 854-1019 Sentence denotes However, we found that gp330 (purified from human or rat) bound the lipolytic enzyme lipoprotein lipase (LPL) with high affinity (Kd = 6.1 and 2.7 nM, respectively).
T13 1020-1130 Sentence denotes The binding was saturable, divalent cation dependent, and inhibited by heparin or receptor-associated protein.
T13 1020-1130 Sentence denotes The binding was saturable, divalent cation dependent, and inhibited by heparin or receptor-associated protein.
T14 1131-1262 Sentence denotes Because LRP has also been shown to bind LPL, the present findings further extend the functional similarities between gp330 and LRP.
T14 1131-1262 Sentence denotes Because LRP has also been shown to bind LPL, the present findings further extend the functional similarities between gp330 and LRP.
T15 1263-1473 Sentence denotes By analogy to the postulated role of the LRP-LPL interaction in facilitating hepatic clearance of LPL-associated lipoproteins from the blood (Beisiegel, U., Weber, W., and Bengtsson-Olivercrona, G. (1991) Proc.
T15 1263-1473 Sentence denotes By analogy to the postulated role of the LRP-LPL interaction in facilitating hepatic clearance of LPL-associated lipoproteins from the blood (Beisiegel, U., Weber, W., and Bengtsson-Olivercrona, G. (1991) Proc.
T16 1474-1479 Sentence denotes Natl.
T16 1474-1479 Sentence denotes Natl.
T17 1480-1485 Sentence denotes Acad.
T17 1480-1485 Sentence denotes Acad.
T18 1486-1490 Sentence denotes Sci.
T18 1486-1490 Sentence denotes Sci.
T19 1491-1497 Sentence denotes U.S.A.
T19 1491-1497 Sentence denotes U.S.A.
T20 1498-1525 Sentence denotes 88, 8342-8346; Chappell, D.
T20 1498-1525 Sentence denotes 88, 8342-8346; Chappell, D.
T21 1526-1537 Sentence denotes A., Fry, G.
T21 1526-1537 Sentence denotes A., Fry, G.
T22 1538-1553 Sentence denotes L., Waknitz, M.
T22 1538-1553 Sentence denotes L., Waknitz, M.
T23 1554-1569 Sentence denotes A., Iverius, P.
T23 1554-1569 Sentence denotes A., Iverius, P.
T24 1570-1586 Sentence denotes H., Williams, S.
T24 1570-1586 Sentence denotes H., Williams, S.
T25 1587-1609 Sentence denotes E., and Strickland, D.
T25 1587-1609 Sentence denotes E., and Strickland, D.
T26 1610-1622 Sentence denotes K. (1992) J.
T26 1610-1622 Sentence denotes K. (1992) J.
T27 1623-1628 Sentence denotes Biol.
T27 1623-1628 Sentence denotes Biol.
T28 1629-1634 Sentence denotes Chem.
T28 1629-1634 Sentence denotes Chem.
T29 1635-1803 Sentence denotes 267, 25764-25767), we speculate that the gp330-LPL interaction described herein may contribute to the uptake of LPL-associated lipoproteins in tissues expressing gp330.
T29 1635-1803 Sentence denotes 267, 25764-25767), we speculate that the gp330-LPL interaction described herein may contribute to the uptake of LPL-associated lipoproteins in tissues expressing gp330.
T30 1804-1912 Sentence denotes Consistent with this possibility, we found that LPL promoted in vitro binding of 125I-lipoproteins to gp330.
T30 1804-1912 Sentence denotes Consistent with this possibility, we found that LPL promoted in vitro binding of 125I-lipoproteins to gp330.