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PubMed:7673240 JSONTXT 29 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-123 Sentence denotes A regulatory element in the human interleukin 2 gene promoter is a binding site for the zinc finger proteins Sp1 and EGR-1.
T1 0-123 Sentence denotes A regulatory element in the human interleukin 2 gene promoter is a binding site for the zinc finger proteins Sp1 and EGR-1.
T2 124-261 Sentence denotes Activation of the interleukin 2 (IL-2) gene after antigen recognition is a critical event for T cell proliferation and effector function.
T2 124-261 Sentence denotes Activation of the interleukin 2 (IL-2) gene after antigen recognition is a critical event for T cell proliferation and effector function.
T3 262-403 Sentence denotes Prior studies have identified several transcription factors that contribute to the activity of the IL-2 promoter in stimulated T lymphocytes.
T3 262-403 Sentence denotes Prior studies have identified several transcription factors that contribute to the activity of the IL-2 promoter in stimulated T lymphocytes.
T4 404-558 Sentence denotes Here we describe a novel regulatory element within the IL-2 promoter located immediately upstream of the nuclear factor of activated T cell (NFAT) domain.
T4 404-558 Sentence denotes Here we describe a novel regulatory element within the IL-2 promoter located immediately upstream of the nuclear factor of activated T cell (NFAT) domain.
T5 559-808 Sentence denotes This region (termed the zinc finger protein binding region (ZIP)) serves as binding site for two differently regulated zinc finger proteins: the constitutively expressed transcription factor Sp1 and the inducible early growth response protein EGR-1.
T5 559-808 Sentence denotes This region (termed the zinc finger protein binding region (ZIP)) serves as binding site for two differently regulated zinc finger proteins: the constitutively expressed transcription factor Sp1 and the inducible early growth response protein EGR-1.
T6 809-982 Sentence denotes In unstimulated cells which do not secrete IL-2, only Sp1 binds to this region, while in stimulated IL-2 secreting cells the inducible EGR-1 protein recognizes this element.
T6 809-982 Sentence denotes In unstimulated cells which do not secrete IL-2, only Sp1 binds to this region, while in stimulated IL-2 secreting cells the inducible EGR-1 protein recognizes this element.
T7 983-1159 Sentence denotes In Jurkat T cells, the ZIP site serves as an activator for IL-2 gene expression, and a combination of ZIP and NFAT binding sites is required for maximal IL-2 promoter activity.
T7 983-1159 Sentence denotes In Jurkat T cells, the ZIP site serves as an activator for IL-2 gene expression, and a combination of ZIP and NFAT binding sites is required for maximal IL-2 promoter activity.
T8 1160-1241 Sentence denotes These results suggest a critical role of the ZIP site for IL-2 promoter activity.
T8 1160-1241 Sentence denotes These results suggest a critical role of the ZIP site for IL-2 promoter activity.