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PubMed:7673209 JSONTXT 22 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-87 Sentence denotes Characterization of the regulatory domain of the gamma-subunit of phosphorylase kinase.
T1 0-87 Sentence denotes Characterization of the regulatory domain of the gamma-subunit of phosphorylase kinase.
T2 88-164 Sentence denotes The two noncontiguous calmodulin-binding subdomains are also autoinhibitory.
T2 88-164 Sentence denotes The two noncontiguous calmodulin-binding subdomains are also autoinhibitory.
T3 165-309 Sentence denotes Phosphorylase kinase is a multimeric protein kinase (alpha 4 beta 4 gamma 4 delta 4) whose enzymatic activity is conferred by its gamma-subunit.
T3 165-309 Sentence denotes Phosphorylase kinase is a multimeric protein kinase (alpha 4 beta 4 gamma 4 delta 4) whose enzymatic activity is conferred by its gamma-subunit.
T4 310-491 Sentence denotes A library of 18 overlapping synthetic peptides spanning residues 277-386 of the gamma-subunit has been prepared to use in identifying important regulatory structures in the protein.
T4 310-491 Sentence denotes A library of 18 overlapping synthetic peptides spanning residues 277-386 of the gamma-subunit has been prepared to use in identifying important regulatory structures in the protein.
T5 492-605 Sentence denotes In the present study, the library was screened to identify regions that might function as autoinhibitory domains.
T5 492-605 Sentence denotes In the present study, the library was screened to identify regions that might function as autoinhibitory domains.
T6 606-695 Sentence denotes Peptides from two distinct regions were found to inhibit the Ca2(+)-activated holoenzyme.
T6 606-695 Sentence denotes Peptides from two distinct regions were found to inhibit the Ca2(+)-activated holoenzyme.
T7 696-791 Sentence denotes The same regions were previously found to bind calmodulin (i.e. the delta-subunit; Dasgupta, M.
T7 696-791 Sentence denotes The same regions were previously found to bind calmodulin (i.e. the delta-subunit; Dasgupta, M.
T8 792-825 Sentence denotes Honeycutt, T., and Blumenthal, D.
T8 792-825 Sentence denotes Honeycutt, T., and Blumenthal, D.
T9 826-838 Sentence denotes K. (1989) J.
T9 826-838 Sentence denotes K. (1989) J.
T10 839-844 Sentence denotes Biol.
T10 839-844 Sentence denotes Biol.
T11 845-850 Sentence denotes Chem.
T11 845-850 Sentence denotes Chem.
T12 851-869 Sentence denotes 264, 17156-17163).
T12 851-869 Sentence denotes 264, 17156-17163).
T13 870-1003 Sentence denotes The most potent substrate antagonist peptides were PhK13 (residues 302-326; Ki = 300 nM) and PhK5 (residues 342-366; Ki = 20 microM).
T13 870-1003 Sentence denotes The most potent substrate antagonist peptides were PhK13 (residues 302-326; Ki = 300 nM) and PhK5 (residues 342-366; Ki = 20 microM).
T14 1004-1133 Sentence denotes Both peptides inhibited the holoenzyme competitively with respect to phosphorylase b and noncompetitively with respect to Mg.ATP.
T14 1004-1133 Sentence denotes Both peptides inhibited the holoenzyme competitively with respect to phosphorylase b and noncompetitively with respect to Mg.ATP.
T15 1134-1370 Sentence denotes When the pattern of inhibition with both peptides present was analyzed, inhibition was observed to be synergistic and modestly cooperative indicating that the two peptides can simultaneously occupy the protein substrate-binding site(s).
T15 1134-1370 Sentence denotes When the pattern of inhibition with both peptides present was analyzed, inhibition was observed to be synergistic and modestly cooperative indicating that the two peptides can simultaneously occupy the protein substrate-binding site(s).
T16 1371-1679 Sentence denotes These data are consistent with a model in which the regions of the gamma-subunit represented by PhK5 and PhK13 work in concert as regulatory subdomains that transduce Ca2(+)-induced conformational changes in the delta-subunit to the catalytic gamma-subunit through a pseudosubstrate autoinhibitory mechanism.
T16 1371-1679 Sentence denotes These data are consistent with a model in which the regions of the gamma-subunit represented by PhK5 and PhK13 work in concert as regulatory subdomains that transduce Ca2(+)-induced conformational changes in the delta-subunit to the catalytic gamma-subunit through a pseudosubstrate autoinhibitory mechanism.