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PubMed:7673116 JSONTXT 21 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-136 Sentence denotes A composite Ets/Pit-1 binding site in the prolactin gene can mediate transcriptional responses to multiple signal transduction pathways.
T1 0-136 Sentence denotes A composite Ets/Pit-1 binding site in the prolactin gene can mediate transcriptional responses to multiple signal transduction pathways.
T2 137-279 Sentence denotes Binding sites for the tissue-specific transcription factor, Pit-1, are required for basal and hormonally induced prolactin gene transcription.
T2 137-279 Sentence denotes Binding sites for the tissue-specific transcription factor, Pit-1, are required for basal and hormonally induced prolactin gene transcription.
T3 280-462 Sentence denotes Although Pit-1 is phosphorylated in response to several signaling pathways, the mechanism by which Pit-1 contributes to hormonal induction of gene transcription has not been defined.
T3 280-462 Sentence denotes Although Pit-1 is phosphorylated in response to several signaling pathways, the mechanism by which Pit-1 contributes to hormonal induction of gene transcription has not been defined.
T4 463-586 Sentence denotes Recent reports suggest that phosphorylation of Pit-1 may not be required for hormonal regulation of the prolactin promoter.
T4 463-586 Sentence denotes Recent reports suggest that phosphorylation of Pit-1 may not be required for hormonal regulation of the prolactin promoter.
T5 587-736 Sentence denotes Analysis of the contribution of individual Pit-1 binding sites has been complicated due to the fact that some of the elements appear to be redundant.
T5 587-736 Sentence denotes Analysis of the contribution of individual Pit-1 binding sites has been complicated due to the fact that some of the elements appear to be redundant.
T6 737-993 Sentence denotes To better understand the role of Pit-1 sites in mediating hormonal regulation of the prolactin gene, we have performed enhancer tests using the three most proximal Pit-1 binding sites of the rat prolactin gene which are designated the 1P, 2P, and 3P sites.
T6 737-993 Sentence denotes To better understand the role of Pit-1 sites in mediating hormonal regulation of the prolactin gene, we have performed enhancer tests using the three most proximal Pit-1 binding sites of the rat prolactin gene which are designated the 1P, 2P, and 3P sites.
T7 994-1181 Sentence denotes The results demonstrate that multimers of the 3P Pit-1 binding site are much more responsive to several hormonal and intracellular signaling pathways than multimers of the 1P or 2P sites.
T7 994-1181 Sentence denotes The results demonstrate that multimers of the 3P Pit-1 binding site are much more responsive to several hormonal and intracellular signaling pathways than multimers of the 1P or 2P sites.
T8 1182-1278 Sentence denotes The 3P DNA element was found to contain a consensus binding site for the Ets family of proteins.
T8 1182-1278 Sentence denotes The 3P DNA element was found to contain a consensus binding site for the Ets family of proteins.
T9 1279-1442 Sentence denotes Mutation of the Ets binding site greatly decreased the ability of epidermal growth factor, phorbol esters, Ras, or the Raf kinase to induce reporter gene activity.
T9 1279-1442 Sentence denotes Mutation of the Ets binding site greatly decreased the ability of epidermal growth factor, phorbol esters, Ras, or the Raf kinase to induce reporter gene activity.
T10 1443-1513 Sentence denotes Mutation of the Ets site had little effect on basal enhancer activity.
T10 1443-1513 Sentence denotes Mutation of the Ets site had little effect on basal enhancer activity.
T11 1514-1640 Sentence denotes In contrast, mutation of the consensus Pit-1 binding site in the 3P element essentially abolished all basal enhancer activity.
T11 1514-1640 Sentence denotes In contrast, mutation of the consensus Pit-1 binding site in the 3P element essentially abolished all basal enhancer activity.
T12 1641-1754 Sentence denotes Overexpression of Ets-1 in GH3 pituitary cells enhanced both basal and Ras induced activity from the 3P enhancer.
T12 1641-1754 Sentence denotes Overexpression of Ets-1 in GH3 pituitary cells enhanced both basal and Ras induced activity from the 3P enhancer.
T13 1755-2028 Sentence denotes These data describe a composite element in the prolactin gene containing binding sites for two different factors and the studies suggest a mechanism by which Ets proteins and Pit-1 functionally cooperate to permit transcriptional regulation by different signaling pathways.
T13 1755-2028 Sentence denotes These data describe a composite element in the prolactin gene containing binding sites for two different factors and the studies suggest a mechanism by which Ets proteins and Pit-1 functionally cooperate to permit transcriptional regulation by different signaling pathways.