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PubMed:7665588 JSONTXT 29 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-85 Sentence denotes Ubiquitin-mediated processing of NF-kappa B transcriptional activator precursor p105.
T1 0-85 Sentence denotes Ubiquitin-mediated processing of NF-kappa B transcriptional activator precursor p105.
T2 86-246 Sentence denotes Reconstitution of a cell-free system and identification of the ubiquitin-carrier protein, E2, and a novel ubiquitin-protein ligase, E3, involved in conjugation.
T2 86-246 Sentence denotes Reconstitution of a cell-free system and identification of the ubiquitin-carrier protein, E2, and a novel ubiquitin-protein ligase, E3, involved in conjugation.
T3 247-461 Sentence denotes In most cases, the transcriptional factor NF-kappa B is a heterodimer consisting of two subunits, p50 and p65, which are encoded by two distinct genes of the Rel family. p50 is translated as a precursor of 105 kDa.
T3 247-461 Sentence denotes In most cases, the transcriptional factor NF-kappa B is a heterodimer consisting of two subunits, p50 and p65, which are encoded by two distinct genes of the Rel family. p50 is translated as a precursor of 105 kDa.
T4 462-604 Sentence denotes The C-terminal domain of the precursor is rapidly degraded, forming the mature p50 subunit consisted of the N-terminal region of the molecule.
T4 462-604 Sentence denotes The C-terminal domain of the precursor is rapidly degraded, forming the mature p50 subunit consisted of the N-terminal region of the molecule.
T5 605-653 Sentence denotes The mechanism of generation of p50 is not known.
T5 605-653 Sentence denotes The mechanism of generation of p50 is not known.
T6 654-881 Sentence denotes It has been suggested that the ubiquitin-proteasome system is involved in the process; however, the specific enzymes involved and the mechanism of limited proteolysis, in which half of the molecule is spared, have been obscure.
T6 654-881 Sentence denotes It has been suggested that the ubiquitin-proteasome system is involved in the process; however, the specific enzymes involved and the mechanism of limited proteolysis, in which half of the molecule is spared, have been obscure.
T7 882-923 Sentence denotes Palombella and colleagues (Palombella, V.
T7 882-923 Sentence denotes Palombella and colleagues (Palombella, V.
T8 924-937 Sentence denotes J., Rando, O.
T8 924-937 Sentence denotes J., Rando, O.
T9 938-954 Sentence denotes J., Goldberg, A.
T9 938-954 Sentence denotes J., Goldberg, A.
T10 955-1139 Sentence denotes L., and Maniatis, T. (1994) Cell 78, 773-785) have shown that ubiquitin is required for the processing in a cell-free system of a truncated, artificially constructed, 60-kDa precursor.
T10 955-1139 Sentence denotes L., and Maniatis, T. (1994) Cell 78, 773-785) have shown that ubiquitin is required for the processing in a cell-free system of a truncated, artificially constructed, 60-kDa precursor.
T11 1140-1235 Sentence denotes They have also shown that proteasome inhibitors block the processing both in vitro and in vivo.
T11 1140-1235 Sentence denotes They have also shown that proteasome inhibitors block the processing both in vitro and in vivo.
T12 1236-1849 Sentence denotes In this study, we demonstrate reconstitution of a cell-free processing system and demonstrate directly that: (a) the ubiquitin-proteasome system is involved in processing of the intact p105 precursor, (b) conjugation of ubiquitin to the precursor is an essential intermediate step in the processing, (c) the recently discovered novel species of the ubiquitin-carrier protein, E2-F1, that is involved in the conjugation and degradation of p53, is also required for the limited processing of the p105 precursor, and (d) a novel, approximately 320-kDa species of ubiquitin-protein ligase, is involved in the process.
T12 1236-1849 Sentence denotes In this study, we demonstrate reconstitution of a cell-free processing system and demonstrate directly that: (a) the ubiquitin-proteasome system is involved in processing of the intact p105 precursor, (b) conjugation of ubiquitin to the precursor is an essential intermediate step in the processing, (c) the recently discovered novel species of the ubiquitin-carrier protein, E2-F1, that is involved in the conjugation and degradation of p53, is also required for the limited processing of the p105 precursor, and (d) a novel, approximately 320-kDa species of ubiquitin-protein ligase, is involved in the process.
T13 1850-1963 Sentence denotes This novel enzyme is distinct from E6-AP, the p53-conjugating ligase, and from E3 alpha, the "N-end rule" ligase.
T13 1850-1963 Sentence denotes This novel enzyme is distinct from E6-AP, the p53-conjugating ligase, and from E3 alpha, the "N-end rule" ligase.