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PubMed:7657610 JSONTXT 28 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-176 Sentence denotes In vitro splicing deficiency induced by a C to T mutation at position -3 in the intron 10 acceptor site of the phenylalanine hydroxylase gene in a patient with phenylketonuria.
T1 0-176 Sentence denotes In vitro splicing deficiency induced by a C to T mutation at position -3 in the intron 10 acceptor site of the phenylalanine hydroxylase gene in a patient with phenylketonuria.
TextSentencer_T2 177-352 Sentence denotes A previous study has identified a C-->U mutation at position -3 in the 3' splice site of intron 10 of the phenylalanine hydroxylase pre-mRNA in a patient with phenylketonuria.
T2 177-352 Sentence denotes A previous study has identified a C-->U mutation at position -3 in the 3' splice site of intron 10 of the phenylalanine hydroxylase pre-mRNA in a patient with phenylketonuria.
TextSentencer_T3 353-420 Sentence denotes In vivo, this mutation induces the skipping of the downstream exon.
T3 353-420 Sentence denotes In vivo, this mutation induces the skipping of the downstream exon.
TextSentencer_T4 421-528 Sentence denotes This result is puzzling because both CAG and UAG have been reported to function equally as 3' splice sites.
T4 421-528 Sentence denotes This result is puzzling because both CAG and UAG have been reported to function equally as 3' splice sites.
TextSentencer_T5 529-697 Sentence denotes In this report, we show that the C-->U mutation affects predominantly the first step of the splicing reaction and that it blocks spliceosome assembly at an early stage.
T5 529-697 Sentence denotes In this report, we show that the C-->U mutation affects predominantly the first step of the splicing reaction and that it blocks spliceosome assembly at an early stage.
TextSentencer_T6 698-957 Sentence denotes The 3' region of the phenylalanine hydroxylase intron 10 has two unusual characteristic features: multiple potential branch sites and a series of four guanosine residues, which interrupt the polypyrimidine tract at positions -8 to -11 from the 3' splice site.
T6 698-957 Sentence denotes The 3' region of the phenylalanine hydroxylase intron 10 has two unusual characteristic features: multiple potential branch sites and a series of four guanosine residues, which interrupt the polypyrimidine tract at positions -8 to -11 from the 3' splice site.
TextSentencer_T7 958-1072 Sentence denotes We show that the mutation precludes the use of the proximal branch site, while having no effect on the remote one.
T7 958-1072 Sentence denotes We show that the mutation precludes the use of the proximal branch site, while having no effect on the remote one.
TextSentencer_T8 1073-1176 Sentence denotes We also show that in the UAG transcript, the four guanosine residues inhibit the splicing of intron 10.
T8 1073-1176 Sentence denotes We also show that in the UAG transcript, the four guanosine residues inhibit the splicing of intron 10.
TextSentencer_T9 1177-1388 Sentence denotes The substitution of these purine residues by one cytosine residue, regardless of the position, increases the splicing efficiency of the mutant UAG precursor while having no effect on the wild-type CAG precursor.
T9 1177-1388 Sentence denotes The substitution of these purine residues by one cytosine residue, regardless of the position, increases the splicing efficiency of the mutant UAG precursor while having no effect on the wild-type CAG precursor.
TextSentencer_T10 1389-1519 Sentence denotes Substituting the four purine residues by four pyrimidines relieves the inhibition and rescues the use of the proximal branch site.
T10 1389-1519 Sentence denotes Substituting the four purine residues by four pyrimidines relieves the inhibition and rescues the use of the proximal branch site.
TextSentencer_T11 1520-1663 Sentence denotes These results demonstrate that according to the context, the C and U nucleotides preceding the AG are not equivalent for the splicing reaction.
T11 1520-1663 Sentence denotes These results demonstrate that according to the context, the C and U nucleotides preceding the AG are not equivalent for the splicing reaction.