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PubMed:7642615 JSONTXT 30 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-86 Sentence denotes HIV-1 envelope glycoproteins induce activation of activated protein-1 in CD4+ T cells.
T1 0-86 Sentence denotes HIV-1 envelope glycoproteins induce activation of activated protein-1 in CD4+ T cells.
T2 87-473 Sentence denotes Activation of CD4 positive T cells is a primary requirement for human immunodeficiency virus (HIV) entry, efficient HIV replication, and progression to AIDS, Utilizing CD4 positive T cell lines and purified T cells from normal individuals, we have demonstrated that native envelope glycoproteins of HIV, gp 160, can induce activation of transcription factor, activated protein-1 (AP-1).
T2 87-473 Sentence denotes Activation of CD4 positive T cells is a primary requirement for human immunodeficiency virus (HIV) entry, efficient HIV replication, and progression to AIDS, Utilizing CD4 positive T cell lines and purified T cells from normal individuals, we have demonstrated that native envelope glycoproteins of HIV, gp 160, can induce activation of transcription factor, activated protein-1 (AP-1).
T3 474-679 Sentence denotes The stimulatory effects of gp160 are mediated through the CD4 molecule, since treatment of gp160 with soluble CD4-IgG abrogates its activity, and CD4 negative T cell lines fail to be stimulated with gp160.
T3 474-679 Sentence denotes The stimulatory effects of gp160 are mediated through the CD4 molecule, since treatment of gp160 with soluble CD4-IgG abrogates its activity, and CD4 negative T cell lines fail to be stimulated with gp160.
T4 680-870 Sentence denotes Immunoprecipitation of the gp 160-induced nuclear extracts with polyclonal antibodies to Fos and Jun proteins indicates that AP-1 complex is comprised of members of these family of proteins.
T4 680-870 Sentence denotes Immunoprecipitation of the gp 160-induced nuclear extracts with polyclonal antibodies to Fos and Jun proteins indicates that AP-1 complex is comprised of members of these family of proteins.
T5 871-990 Sentence denotes The gp160-induced AP-1 complex is dependent upon protein tyrosine phosphorylation and is protein synthesis-independent.
T5 871-990 Sentence denotes The gp160-induced AP-1 complex is dependent upon protein tyrosine phosphorylation and is protein synthesis-independent.
T6 991-1131 Sentence denotes This stimulation can also be abolished by inhibitors of protein kinase C, but it is unaffected by calcium channel blocker or cyclosporine A.
T6 991-1131 Sentence denotes This stimulation can also be abolished by inhibitors of protein kinase C, but it is unaffected by calcium channel blocker or cyclosporine A.
T7 1132-1327 Sentence denotes This gp160 treatment adversely affects the functional capabilities of T cells: pre-treatment of CD4+ T cells with gp160 for 4 h at 37 degrees C inhibited anti-CD3-induced interleukin-2 secretion.
T7 1132-1327 Sentence denotes This gp160 treatment adversely affects the functional capabilities of T cells: pre-treatment of CD4+ T cells with gp160 for 4 h at 37 degrees C inhibited anti-CD3-induced interleukin-2 secretion.
T8 1328-1381 Sentence denotes Effects similar to gp160 were seen with anti-CD4 mAb.
T8 1328-1381 Sentence denotes Effects similar to gp160 were seen with anti-CD4 mAb.
T9 1382-1673 Sentence denotes The aberrant activation of AP-1 by gp160 in CD4 positive T cells could result in up-regulation of cytokines containing AP-1 sites, e.g. interleukin-3 and granulocyte macrophage colony-stimulating factor, and concurrently lead to T cell unresponsiveness by inhibiting interleukin-2 secretion.
T9 1382-1673 Sentence denotes The aberrant activation of AP-1 by gp160 in CD4 positive T cells could result in up-regulation of cytokines containing AP-1 sites, e.g. interleukin-3 and granulocyte macrophage colony-stimulating factor, and concurrently lead to T cell unresponsiveness by inhibiting interleukin-2 secretion.