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PubMed:7592676 JSONTXT 29 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-117 Sentence denotes Multiple proteins interact with the nuclear inhibitory protein repressor element in the human interleukin-3 promoter.
T1 0-117 Sentence denotes Multiple proteins interact with the nuclear inhibitory protein repressor element in the human interleukin-3 promoter.
T2 118-287 Sentence denotes T cell expression of interleukin 3 (IL-3) is directed by positive and negative cis-acting DNA elements clustered within 300 base pairs of the transcriptional start site.
T2 118-287 Sentence denotes T cell expression of interleukin 3 (IL-3) is directed by positive and negative cis-acting DNA elements clustered within 300 base pairs of the transcriptional start site.
T3 288-447 Sentence denotes A strong repressor element, termed nuclear inhibitory protein (NIP), was previously mapped to a segment of the IL-3 promoter between nucleotides -271 and -250.
T3 288-447 Sentence denotes A strong repressor element, termed nuclear inhibitory protein (NIP), was previously mapped to a segment of the IL-3 promoter between nucleotides -271 and -250.
T4 448-582 Sentence denotes Functional characterization of this element demonstrates that it can mediate repression when linked in cis to a heterologous promoter.
T4 448-582 Sentence denotes Functional characterization of this element demonstrates that it can mediate repression when linked in cis to a heterologous promoter.
T5 583-663 Sentence denotes DNA binding experiments were carried out to characterize the repressor activity.
T5 583-663 Sentence denotes DNA binding experiments were carried out to characterize the repressor activity.
T6 664-825 Sentence denotes Using varying conditions, three distinct complexes were shown to interact specifically with the NIP region, although only one correlates with repressor activity.
T6 664-825 Sentence denotes Using varying conditions, three distinct complexes were shown to interact specifically with the NIP region, although only one correlates with repressor activity.
T7 826-968 Sentence denotes Complex 1 results from binding of a ubiquitous polypeptide that recognizes the 3' portion of this sequence and is not required for repression.
T7 826-968 Sentence denotes Complex 1 results from binding of a ubiquitous polypeptide that recognizes the 3' portion of this sequence and is not required for repression.
T8 969-1110 Sentence denotes Complex 2 corresponds to binding of transcription factor (upstream stimulatory factor) to an E-box motif in the 5' portion of the NIP region.
T8 969-1110 Sentence denotes Complex 2 corresponds to binding of transcription factor (upstream stimulatory factor) to an E-box motif in the 5' portion of the NIP region.
T9 1111-1222 Sentence denotes DNA binding specificity of complex 3 overlaps with that of upstream stimulatory factor but is clearly distinct.
T9 1111-1222 Sentence denotes DNA binding specificity of complex 3 overlaps with that of upstream stimulatory factor but is clearly distinct.
T10 1223-1447 Sentence denotes To determine which of the latter two complexes represents NIP activity, we incorporated small alterations into the NIP site of an IL-3 promoter-linked reporter construct and examined their effects on NIP-mediated repression.
T10 1223-1447 Sentence denotes To determine which of the latter two complexes represents NIP activity, we incorporated small alterations into the NIP site of an IL-3 promoter-linked reporter construct and examined their effects on NIP-mediated repression.
T11 1448-1623 Sentence denotes Functional specificity for repression matches the DNA binding specificity of complex 3; both repressor activity and complex 3 binding require the consensus sequence CTCACNTNC.
T11 1448-1623 Sentence denotes Functional specificity for repression matches the DNA binding specificity of complex 3; both repressor activity and complex 3 binding require the consensus sequence CTCACNTNC.