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PubMed:7592631 JSONTXT 36 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-98 Sentence denotes Specific recognition of N-acetylneuraminic acid in the GM2 epitope by human GM2 activator protein.
T1 0-98 Sentence denotes Specific recognition of N-acetylneuraminic acid in the GM2 epitope by human GM2 activator protein.
T2 99-399 Sentence denotes GM2 Activator is a low molecular weight protein cofactor that stimulates the enzymatic conversion of GM2 into GM3 by human beta-hexosaminidase A and also the conversion of GM2 into GA2 by clostridial sialidase (Wu, Y.-Y., Lockyer, J.M., Sugiyama, E., Pavlova, N.V., Li, Y.-T., and Li, S.-C. (1994) J.
T2 99-399 Sentence denotes GM2 Activator is a low molecular weight protein cofactor that stimulates the enzymatic conversion of GM2 into GM3 by human beta-hexosaminidase A and also the conversion of GM2 into GA2 by clostridial sialidase (Wu, Y.-Y., Lockyer, J.M., Sugiyama, E., Pavlova, N.V., Li, Y.-T., and Li, S.-C. (1994) J.
T3 400-405 Sentence denotes Biol.
T3 400-405 Sentence denotes Biol.
T4 406-411 Sentence denotes Chem.
T4 406-411 Sentence denotes Chem.
T5 412-430 Sentence denotes 269, 16276-16283).
T5 412-430 Sentence denotes 269, 16276-16283).
T6 431-592 Sentence denotes Among the five known activator proteins for the enzymatic hydrolysis of glycosphingolipids, only GM2 activator is effective in stimulating the hydrolysis of GM2.
T6 431-592 Sentence denotes Among the five known activator proteins for the enzymatic hydrolysis of glycosphingolipids, only GM2 activator is effective in stimulating the hydrolysis of GM2.
T7 593-672 Sentence denotes However, the mechanism of action of GM2 activator is still not well understood.
T7 593-672 Sentence denotes However, the mechanism of action of GM2 activator is still not well understood.
T8 673-1017 Sentence denotes Using a unique disialosylganglioside, GalNAc-GD1a, as the substrate, we were able to show that in the presence of GM2 activator, GalNAc-GD1a was specifically converted into GalNAc-GM1a by clostridial sialidase, while in the presence of saposin B, a nonspecific activator protein, GalNAc-GD1a was converted into both GalNAc-GM1a and GalNAc-GM1b.
T8 673-1017 Sentence denotes Using a unique disialosylganglioside, GalNAc-GD1a, as the substrate, we were able to show that in the presence of GM2 activator, GalNAc-GD1a was specifically converted into GalNAc-GM1a by clostridial sialidase, while in the presence of saposin B, a nonspecific activator protein, GalNAc-GD1a was converted into both GalNAc-GM1a and GalNAc-GM1b.
T9 1018-1251 Sentence denotes Individual products generated from GalNAc-GD1a by clostridial sialidase were identified by thin layer chromatography, negative secondary ion mass spectrometry, and immunostaining with a monoclonal IgM that recognizes the GM2 epitope.
T9 1018-1251 Sentence denotes Individual products generated from GalNAc-GD1a by clostridial sialidase were identified by thin layer chromatography, negative secondary ion mass spectrometry, and immunostaining with a monoclonal IgM that recognizes the GM2 epitope.
T10 1252-1338 Sentence denotes Our results clearly show that GM2 activator recognizes the GM2 epitope in GalNAc-GD1a.
T10 1252-1338 Sentence denotes Our results clearly show that GM2 activator recognizes the GM2 epitope in GalNAc-GD1a.
T11 1339-1529 Sentence denotes Thus, GM2 activator may interact with the trisaccharide structure of the GM2 epitope and render the GalNAc and NeuAc residues accessible to beta-hexosaminidase A and sialidase, respectively.
T11 1339-1529 Sentence denotes Thus, GM2 activator may interact with the trisaccharide structure of the GM2 epitope and render the GalNAc and NeuAc residues accessible to beta-hexosaminidase A and sialidase, respectively.