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PubMed:7539796 JSONTXT 22 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-176 Sentence denotes Localization of functional receptor epitopes on the structure of ciliary neurotrophic factor indicates a conserved, function-related epitope topography among helical cytokines.
T1 0-176 Sentence denotes Localization of functional receptor epitopes on the structure of ciliary neurotrophic factor indicates a conserved, function-related epitope topography among helical cytokines.
T2 177-486 Sentence denotes By rational mutagenesis, receptor-specific functional analysis, and visualization of complex formation in solution, we identified individual amino acid side chains involved specifically in the interaction of ciliary neurotrophic factor (CNTF) with CNTFR alpha and not with the beta-components, gp130 and LIFR.
T2 177-486 Sentence denotes By rational mutagenesis, receptor-specific functional analysis, and visualization of complex formation in solution, we identified individual amino acid side chains involved specifically in the interaction of ciliary neurotrophic factor (CNTF) with CNTFR alpha and not with the beta-components, gp130 and LIFR.
T3 487-709 Sentence denotes In the crystal structure, the side chains of these residues, which are located in helix A, the AB loop, helix B, and helix D, are surface accessible and are clustered in space, thus constituting an epitope for CNTFR alpha.
T3 487-709 Sentence denotes In the crystal structure, the side chains of these residues, which are located in helix A, the AB loop, helix B, and helix D, are surface accessible and are clustered in space, thus constituting an epitope for CNTFR alpha.
T4 710-845 Sentence denotes By the same analysis, a partial epitope for gp130 was also identified on the surface of helix A that faces away from the alpha-epitope.
T4 710-845 Sentence denotes By the same analysis, a partial epitope for gp130 was also identified on the surface of helix A that faces away from the alpha-epitope.
T5 846-1057 Sentence denotes Superposition of the CNTF and growth hormone structures showed that the location of these epitopes on CNTF is analogous to the location of the first and second receptor epitopes on the surface of growth hormone.
T5 846-1057 Sentence denotes Superposition of the CNTF and growth hormone structures showed that the location of these epitopes on CNTF is analogous to the location of the first and second receptor epitopes on the surface of growth hormone.
T6 1058-1257 Sentence denotes Further comparison with proposed binding sites for alpha- and beta-receptors on interleukin-6 and leukemia inhibitory factor indicated that this epitope topology is conserved among helical cytokines.
T6 1058-1257 Sentence denotes Further comparison with proposed binding sites for alpha- and beta-receptors on interleukin-6 and leukemia inhibitory factor indicated that this epitope topology is conserved among helical cytokines.
T7 1258-1396 Sentence denotes In each case, epitope I is utilized by the specificity-conferring component, whereas epitopes II and III are used by accessory components.
T7 1258-1396 Sentence denotes In each case, epitope I is utilized by the specificity-conferring component, whereas epitopes II and III are used by accessory components.
T8 1397-1521 Sentence denotes Thus, in addition to a common fold, helical cytokines share a conserved order of receptor epitopes that is function related.
T8 1397-1521 Sentence denotes Thus, in addition to a common fold, helical cytokines share a conserved order of receptor epitopes that is function related.