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PubMed:7520914 JSONTXT 30 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-126 Sentence denotes CD14-mediated translocation of nuclear factor-kappa B induced by lipopolysaccharide does not require tyrosine kinase activity.
T1 0-126 Sentence denotes CD14-mediated translocation of nuclear factor-kappa B induced by lipopolysaccharide does not require tyrosine kinase activity.
T2 127-374 Sentence denotes During the course of serious bacterial infections, lipopolysaccharide (LPS) is believed to interact with macrophage receptors, resulting in the generation of inflammatory mediators and systemic symptoms including hemodynamic instability and shock.
T2 127-374 Sentence denotes During the course of serious bacterial infections, lipopolysaccharide (LPS) is believed to interact with macrophage receptors, resulting in the generation of inflammatory mediators and systemic symptoms including hemodynamic instability and shock.
T3 375-467 Sentence denotes CD14, a glycosylphosphatidylinositol-linked antigen, functions as an LPS signaling receptor.
T3 375-467 Sentence denotes CD14, a glycosylphosphatidylinositol-linked antigen, functions as an LPS signaling receptor.
T4 468-602 Sentence denotes A critical issue concerns the mechanism by which CD14, which has no transmembrane domain, transduces its signal following LPS binding.
T4 468-602 Sentence denotes A critical issue concerns the mechanism by which CD14, which has no transmembrane domain, transduces its signal following LPS binding.
T5 603-798 Sentence denotes Recently, investigators have hypothesized that CD14-mediated signaling is effected through a receptor-associated tyrosine kinase (TK), suggesting a multicomponent receptor model of LPS signaling.
T5 603-798 Sentence denotes Recently, investigators have hypothesized that CD14-mediated signaling is effected through a receptor-associated tyrosine kinase (TK), suggesting a multicomponent receptor model of LPS signaling.
T6 799-950 Sentence denotes Wild-type Chinese hamster ovary (CHO)-K1 cells can be activated by endotoxin to release arachidonate following transfection with human CD14 (CHO/CD14).
T6 799-950 Sentence denotes Wild-type Chinese hamster ovary (CHO)-K1 cells can be activated by endotoxin to release arachidonate following transfection with human CD14 (CHO/CD14).
T7 951-1052 Sentence denotes Nuclear translocation of cytosolic NF-kappa B is correlated with a number of LPS-inducible responses.
T7 951-1052 Sentence denotes Nuclear translocation of cytosolic NF-kappa B is correlated with a number of LPS-inducible responses.
T8 1053-1210 Sentence denotes We sought to determine if this pathway were present in CHO/CD14 cells and to elucidate the relationship of NF-kappa B activation to the CD14 receptor system.
T8 1053-1210 Sentence denotes We sought to determine if this pathway were present in CHO/CD14 cells and to elucidate the relationship of NF-kappa B activation to the CD14 receptor system.
T9 1211-1350 Sentence denotes LPS-stimulated translocation of NF-kappa B in CHO/CD14 cells resembled the same response in the murine macrophage-like cell line RAW 264.7.
T9 1211-1350 Sentence denotes LPS-stimulated translocation of NF-kappa B in CHO/CD14 cells resembled the same response in the murine macrophage-like cell line RAW 264.7.
T10 1351-1624 Sentence denotes Protein synthesis inhibitors and corticosteroids, which suppress arachidonate release and the synthesis of proinflammatory cytokines, had no effect on translocation of NF-kappa B in CHO/CD14 or RAW 264.7 cells, demonstrating that NF-kappa B translocation is an early event.
T10 1351-1624 Sentence denotes Protein synthesis inhibitors and corticosteroids, which suppress arachidonate release and the synthesis of proinflammatory cytokines, had no effect on translocation of NF-kappa B in CHO/CD14 or RAW 264.7 cells, demonstrating that NF-kappa B translocation is an early event.
T11 1625-1824 Sentence denotes Although TK activity was consistently observed by immunoblotting extracts from activated RAW 264.7 cells, LPS-induced phosphotyrosine residues were not observed from similarly treated CHO/CD14 cells.
T11 1625-1824 Sentence denotes Although TK activity was consistently observed by immunoblotting extracts from activated RAW 264.7 cells, LPS-induced phosphotyrosine residues were not observed from similarly treated CHO/CD14 cells.
T12 1825-2044 Sentence denotes Furthermore, the TK inhibitors herbimycin A and genistein failed to inhibit translocation of NF-kappa B in CHO/CD14 or RAW 264.7 cells, although both of these agents inhibited LPS-induced TK activity in RAW 264.7 cells.
T12 1825-2044 Sentence denotes Furthermore, the TK inhibitors herbimycin A and genistein failed to inhibit translocation of NF-kappa B in CHO/CD14 or RAW 264.7 cells, although both of these agents inhibited LPS-induced TK activity in RAW 264.7 cells.
T13 2045-2166 Sentence denotes These results imply that TK activity is not obligatory for CD14-mediated signal transduction to occur in response to LPS.
T13 2045-2166 Sentence denotes These results imply that TK activity is not obligatory for CD14-mediated signal transduction to occur in response to LPS.