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PubMed:7512565 JSONTXT 30 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-77 Sentence denotes Sp1 is a critical factor for the monocytic specific expression of human CD14.
T1 0-77 Sentence denotes Sp1 is a critical factor for the monocytic specific expression of human CD14.
T2 78-251 Sentence denotes CD14 is a membrane glycoprotein expressed specifically on monocytes and macrophages, and its expression is markedly increased during the process of monocyte differentiation.
T2 78-251 Sentence denotes CD14 is a membrane glycoprotein expressed specifically on monocytes and macrophages, and its expression is markedly increased during the process of monocyte differentiation.
T3 252-374 Sentence denotes In order to study CD14 gene regulation, the human CD14 gene was cloned from a partial EcoRI digested chromosome 5 library.
T3 252-374 Sentence denotes In order to study CD14 gene regulation, the human CD14 gene was cloned from a partial EcoRI digested chromosome 5 library.
T4 375-493 Sentence denotes A 5.5-kilobase genomic clone contained the full-length CD14 coding sequence and 4.2 kilobases of 5'-upstream sequence.
T4 375-493 Sentence denotes A 5.5-kilobase genomic clone contained the full-length CD14 coding sequence and 4.2 kilobases of 5'-upstream sequence.
T5 494-650 Sentence denotes One major and one minor transcription start site were identified 101 and 130 base pairs (bp) upstream, respectively, from the protein translation start ATG.
T5 494-650 Sentence denotes One major and one minor transcription start site were identified 101 and 130 base pairs (bp) upstream, respectively, from the protein translation start ATG.
T6 651-861 Sentence denotes A DNA fragment containing 128 bp of upstream sequence had strong, monocyte-specific promoter activity in the CD14 positive monocytic cell line Mono Mac 6 as compared to the nonmonocytic cell lines HeLa and REX.
T6 651-861 Sentence denotes A DNA fragment containing 128 bp of upstream sequence had strong, monocyte-specific promoter activity in the CD14 positive monocytic cell line Mono Mac 6 as compared to the nonmonocytic cell lines HeLa and REX.
T7 862-957 Sentence denotes Four regions in this DNA fragment interact with nuclear proteins isolated from monocytic cells.
T7 862-957 Sentence denotes Four regions in this DNA fragment interact with nuclear proteins isolated from monocytic cells.
T8 958-1041 Sentence denotes The Sp1 transcription factor bound to three different regions in the CD14 promoter.
T8 958-1041 Sentence denotes The Sp1 transcription factor bound to three different regions in the CD14 promoter.
T9 1042-1302 Sentence denotes Mutation of the major Sp1 binding site (-110 bp) decreased tissue-specific promoter activity, and these results, together with transactivation experiments, demonstrate that Sp1 plays a critical role in the tissue-specific expression of CD14 in monocytic cells.
T9 1042-1302 Sentence denotes Mutation of the major Sp1 binding site (-110 bp) decreased tissue-specific promoter activity, and these results, together with transactivation experiments, demonstrate that Sp1 plays a critical role in the tissue-specific expression of CD14 in monocytic cells.
T10 1303-1600 Sentence denotes CD14 Sp1 site oligonucleotides bound preferentially to a 105-kDa Sp1 species, which is present in higher relative levels in monocytic than non-monocytic cells, suggesting that modification of Sp1, such as phosphorylation, may explain how the Sp1 site mediates monocytic specific promoter activity.
T10 1303-1600 Sentence denotes CD14 Sp1 site oligonucleotides bound preferentially to a 105-kDa Sp1 species, which is present in higher relative levels in monocytic than non-monocytic cells, suggesting that modification of Sp1, such as phosphorylation, may explain how the Sp1 site mediates monocytic specific promoter activity.