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Id Subject Object Predicate Lexical cue
T1 0-174 Sentence denotes Thrombin and thrombin receptor agonist peptide induce early events of T cell activation and synergize with TCR cross-linking for CD69 expression and interleukin 2 production.
T1 0-174 Sentence denotes Thrombin and thrombin receptor agonist peptide induce early events of T cell activation and synergize with TCR cross-linking for CD69 expression and interleukin 2 production.
T2 175-271 Sentence denotes Thrombin stimulation of the T leukemic cell line Jurkat induced a transient increase in [Ca2+]i.
T2 175-271 Sentence denotes Thrombin stimulation of the T leukemic cell line Jurkat induced a transient increase in [Ca2+]i.
T3 272-406 Sentence denotes Proteolytic activity of the enzyme was required for this effect since diisopropyl fluorophosphate-thrombin failed to increase [Ca2+]i.
T3 272-406 Sentence denotes Proteolytic activity of the enzyme was required for this effect since diisopropyl fluorophosphate-thrombin failed to increase [Ca2+]i.
T4 407-512 Sentence denotes Furthermore, hirudin and anti-thrombin III inhibited the thrombin-induced [Ca2+]i rise in Jurkat T cells.
T4 407-512 Sentence denotes Furthermore, hirudin and anti-thrombin III inhibited the thrombin-induced [Ca2+]i rise in Jurkat T cells.
T5 513-728 Sentence denotes A synthetic thrombin receptor agonist peptide (TRP) of 7 residues (SFLLRNP) was found to be as effective as thrombin for [Ca2+]i mobilization, and both agonists induced Ca2+ release exclusively from internal stores.
T5 513-728 Sentence denotes A synthetic thrombin receptor agonist peptide (TRP) of 7 residues (SFLLRNP) was found to be as effective as thrombin for [Ca2+]i mobilization, and both agonists induced Ca2+ release exclusively from internal stores.
T6 729-841 Sentence denotes Thrombin stimulated tyrosine phosphorylation of several proteins of molecular mass 40, 42, 70, 120, and 130 kDa.
T6 729-841 Sentence denotes Thrombin stimulated tyrosine phosphorylation of several proteins of molecular mass 40, 42, 70, 120, and 130 kDa.
T7 842-972 Sentence denotes There was a good correlation between thrombin-induced tyrosine phosphorylation of the latter three proteins and Ca2+ mobilization.
T7 842-972 Sentence denotes There was a good correlation between thrombin-induced tyrosine phosphorylation of the latter three proteins and Ca2+ mobilization.
T8 973-1076 Sentence denotes Thrombin and TRP also caused translocation of protein kinase C from the cytosol to the plasma membrane.
T8 973-1076 Sentence denotes Thrombin and TRP also caused translocation of protein kinase C from the cytosol to the plasma membrane.
T9 1077-1162 Sentence denotes As a likely consequence of these events, thrombin activated the nuclear factor NF-kB.
T9 1077-1162 Sentence denotes As a likely consequence of these events, thrombin activated the nuclear factor NF-kB.
T10 1163-1449 Sentence denotes Several cell lines of hematopoietic origin including the leukemic T cell line HPB.ALL and the erythroleukemic cell line K562 were responsive to thrombin, whereas others such as THP1, a myelomonocytic cell line, and BL2, a Burkitt lymphoma were refractory to thrombin or TRP stimulation.
T10 1163-1449 Sentence denotes Several cell lines of hematopoietic origin including the leukemic T cell line HPB.ALL and the erythroleukemic cell line K562 were responsive to thrombin, whereas others such as THP1, a myelomonocytic cell line, and BL2, a Burkitt lymphoma were refractory to thrombin or TRP stimulation.
T11 1450-1573 Sentence denotes The magnitude of the thrombin response in the different cell types paralleled the expression of the thrombin receptor mRNA.
T11 1450-1573 Sentence denotes The magnitude of the thrombin response in the different cell types paralleled the expression of the thrombin receptor mRNA.
T12 1574-1809 Sentence denotes We found that activation of Jurkat T cells by a combination of phytohemagglutinin and phorbol 12-myristate 13-acetate led to a dramatic inhibition of thrombin receptor mRNA expression and to a concomitant loss of the thrombin response.
T12 1574-1809 Sentence denotes We found that activation of Jurkat T cells by a combination of phytohemagglutinin and phorbol 12-myristate 13-acetate led to a dramatic inhibition of thrombin receptor mRNA expression and to a concomitant loss of the thrombin response.
T13 1810-2007 Sentence denotes Finally, we demonstrate that thrombin and TRP enhanced CD69 expression and interleukin 2 production induced by T cell receptor cross-linking in both Jurkat T cells and peripheral blood lymphocytes.
T13 1810-2007 Sentence denotes Finally, we demonstrate that thrombin and TRP enhanced CD69 expression and interleukin 2 production induced by T cell receptor cross-linking in both Jurkat T cells and peripheral blood lymphocytes.
T14 2008-2106 Sentence denotes These findings highlight the role of thrombin as a potential regulator of T lymphocyte activation.
T14 2008-2106 Sentence denotes These findings highlight the role of thrombin as a potential regulator of T lymphocyte activation.