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PubMed:7509852 JSONTXT 7 Projects

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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-99 Sentence denotes Sensitive detection of occult breast cancer by the reverse-transcriptase polymerase chain reaction.
T1 0-99 Sentence denotes Sensitive detection of occult breast cancer by the reverse-transcriptase polymerase chain reaction.
TextSentencer_T2 100-108 Sentence denotes PURPOSE:
T2 100-108 Sentence denotes PURPOSE:
TextSentencer_T3 109-255 Sentence denotes Detection of occult carcinoma in patients with breast cancer may aid the establishment of prognosis and development of new therapeutic approaches.
T3 109-255 Sentence denotes Detection of occult carcinoma in patients with breast cancer may aid the establishment of prognosis and development of new therapeutic approaches.
TextSentencer_T4 256-524 Sentence denotes To improve on existing methods of detection, we have developed a reverse-transcriptase polymerase chain reaction (RT-PCR) assay for keratin 19 (K19) transcripts to identify mammary carcinoma cells in the peripheral blood and bone marrow of patients with breast cancer.
T4 256-524 Sentence denotes To improve on existing methods of detection, we have developed a reverse-transcriptase polymerase chain reaction (RT-PCR) assay for keratin 19 (K19) transcripts to identify mammary carcinoma cells in the peripheral blood and bone marrow of patients with breast cancer.
TextSentencer_T5 525-546 Sentence denotes PATIENTS AND METHODS:
T5 525-546 Sentence denotes PATIENTS AND METHODS:
TextSentencer_T6 547-741 Sentence denotes Peripheral-blood or bone marrow samples obtained from 34 patients with stages I to IV breast cancer and 39 control subjects without breast cancer were screened for K19 mRNA by nested primer PCR.
T6 547-741 Sentence denotes Peripheral-blood or bone marrow samples obtained from 34 patients with stages I to IV breast cancer and 39 control subjects without breast cancer were screened for K19 mRNA by nested primer PCR.
TextSentencer_T7 742-750 Sentence denotes RESULTS:
T7 742-750 Sentence denotes RESULTS:
TextSentencer_T8 751-900 Sentence denotes In reconstitution experiments, K19 RT-PCR reliably detected 10 mammary carcinoma cells in 1 million normal peripheral-blood mononuclear (PBMN) cells.
T8 751-900 Sentence denotes In reconstitution experiments, K19 RT-PCR reliably detected 10 mammary carcinoma cells in 1 million normal peripheral-blood mononuclear (PBMN) cells.
TextSentencer_T9 901-999 Sentence denotes Four of 19 patients with stage IV breast cancer had detectable K19 transcript in peripheral blood.
T9 901-999 Sentence denotes Four of 19 patients with stage IV breast cancer had detectable K19 transcript in peripheral blood.
TextSentencer_T10 1000-1185 Sentence denotes Five of six patients with histologically negative bone marrow biopsies following preablative chemotherapy and before autologous bone marrow transplant (BMT) were positive by this assay.
T10 1000-1185 Sentence denotes Five of six patients with histologically negative bone marrow biopsies following preablative chemotherapy and before autologous bone marrow transplant (BMT) were positive by this assay.
TextSentencer_T11 1186-1326 Sentence denotes Stem-cell apheresis harvests obtained from one of these patients and three additional patients immediately before BMT were all K19-negative.
T11 1186-1326 Sentence denotes Stem-cell apheresis harvests obtained from one of these patients and three additional patients immediately before BMT were all K19-negative.
TextSentencer_T12 1327-1437 Sentence denotes K19 RT-PCR analysis of CSF from a breast cancer patient with known carcinomatous meningitis was also positive.
T12 1327-1437 Sentence denotes K19 RT-PCR analysis of CSF from a breast cancer patient with known carcinomatous meningitis was also positive.
TextSentencer_T13 1438-1515 Sentence denotes Thirty-eight of 39 non-breast cancer patients had negative K19 RT-PCR assays.
T13 1438-1515 Sentence denotes Thirty-eight of 39 non-breast cancer patients had negative K19 RT-PCR assays.
TextSentencer_T14 1516-1582 Sentence denotes The one exception was a patient with chronic myelogenous leukemia.
T14 1516-1582 Sentence denotes The one exception was a patient with chronic myelogenous leukemia.
TextSentencer_T15 1583-1771 Sentence denotes CONCLUSION: RT-PCR of K19 is a sensitive, specific, and rapid method for detection of occult mammary carcinoma cells in the peripheral blood and bone marrow of patients with breast cancer.
T15 1583-1771 Sentence denotes CONCLUSION: RT-PCR of K19 is a sensitive, specific, and rapid method for detection of occult mammary carcinoma cells in the peripheral blood and bone marrow of patients with breast cancer.
TextSentencer_T16 1772-1926 Sentence denotes The presence of residual breast cancer cells in histologically normal bone marrow aspirates but not in stem-cell apheresis harvests is a frequent finding.
T16 1772-1926 Sentence denotes The presence of residual breast cancer cells in histologically normal bone marrow aspirates but not in stem-cell apheresis harvests is a frequent finding.
TextSentencer_T17 1927-2049 Sentence denotes This assay may be useful in diagnosing metastatic disease, as well as in monitoring the effectiveness of systemic therapy.
T17 1927-2049 Sentence denotes This assay may be useful in diagnosing metastatic disease, as well as in monitoring the effectiveness of systemic therapy.