| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-118 |
Sentence |
denotes |
rel Is rapidly tyrosine-phosphorylated following granulocyte-colony stimulating factor treatment of human neutrophils. |
| T1 |
0-118 |
Sentence |
denotes |
rel Is rapidly tyrosine-phosphorylated following granulocyte-colony stimulating factor treatment of human neutrophils. |
| T2 |
119-292 |
Sentence |
denotes |
Stimulation of neutrophils with granulocyte-colony stimulating factor (G-CSF) results in an enhanced respiratory burst, prolonged survival, and increased tumor cell killing. |
| T2 |
119-292 |
Sentence |
denotes |
Stimulation of neutrophils with granulocyte-colony stimulating factor (G-CSF) results in an enhanced respiratory burst, prolonged survival, and increased tumor cell killing. |
| T3 |
293-375 |
Sentence |
denotes |
The effects of G-CSF are mediated by binding to specific, high affinity receptors. |
| T3 |
293-375 |
Sentence |
denotes |
The effects of G-CSF are mediated by binding to specific, high affinity receptors. |
| T4 |
376-523 |
Sentence |
denotes |
G-CSF receptors lack intrinsic tyrosine kinase activity, but activation of the receptor results in the rapid induction of tyrosine kinase activity. |
| T4 |
376-523 |
Sentence |
denotes |
G-CSF receptors lack intrinsic tyrosine kinase activity, but activation of the receptor results in the rapid induction of tyrosine kinase activity. |
| T5 |
524-727 |
Sentence |
denotes |
Antiphosphotyrosine immunoblots of whole cell lysates prepared from neutrophils show that the G-CSF rapidly induces prominent tyrosine phosphorylation of a protein of a relative molecular mass of 80 kDa. |
| T5 |
524-727 |
Sentence |
denotes |
Antiphosphotyrosine immunoblots of whole cell lysates prepared from neutrophils show that the G-CSF rapidly induces prominent tyrosine phosphorylation of a protein of a relative molecular mass of 80 kDa. |
| T6 |
728-922 |
Sentence |
denotes |
Using monospecific antibodies, the 80-kDa tyrosine-phosphorylated protein has been shown to be p80c-rel, a proto-oncogene belonging to a family of transcriptional regulators which include NF-kB. |
| T6 |
728-922 |
Sentence |
denotes |
Using monospecific antibodies, the 80-kDa tyrosine-phosphorylated protein has been shown to be p80c-rel, a proto-oncogene belonging to a family of transcriptional regulators which include NF-kB. |
| T7 |
923-1181 |
Sentence |
denotes |
The induction of tyrosine phosphorylation of p80c-rel was unique to G-CSF in that granulocyte-macrophage colony stimulating factor which also stimulates neutrophils and induces tyrosine phosphorylation does not result in tyrosine phosphorylation of p80c-rel. |
| T7 |
923-1181 |
Sentence |
denotes |
The induction of tyrosine phosphorylation of p80c-rel was unique to G-CSF in that granulocyte-macrophage colony stimulating factor which also stimulates neutrophils and induces tyrosine phosphorylation does not result in tyrosine phosphorylation of p80c-rel. |
| T8 |
1182-1417 |
Sentence |
denotes |
The consequences of p80c-rel tyrosine phosphorylation are not yet known; however, tyrosine-phosphorylated p80c-rel is capable of binding to DNA, and G-CSF stimulation results in an increase in the amount of p80c-rel which binds to DNA. |
| T8 |
1182-1417 |
Sentence |
denotes |
The consequences of p80c-rel tyrosine phosphorylation are not yet known; however, tyrosine-phosphorylated p80c-rel is capable of binding to DNA, and G-CSF stimulation results in an increase in the amount of p80c-rel which binds to DNA. |
| T9 |
1418-1634 |
Sentence |
denotes |
These results demonstrate that one of the first biochemical events which occurs in neutrophils following G-CSF stimulation, activation of a tyrosine kinase, leads directly to the tyrosine phosphorylation of p80c-rel. |
| T9 |
1418-1634 |
Sentence |
denotes |
These results demonstrate that one of the first biochemical events which occurs in neutrophils following G-CSF stimulation, activation of a tyrosine kinase, leads directly to the tyrosine phosphorylation of p80c-rel. |
| T10 |
1635-1779 |
Sentence |
denotes |
Thus, the tyrosine kinase activated by G-CSF appears to directly transduce a signal to a protein which functions as a transcriptional regulator. |
| T10 |
1635-1779 |
Sentence |
denotes |
Thus, the tyrosine kinase activated by G-CSF appears to directly transduce a signal to a protein which functions as a transcriptional regulator. |