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Id Subject Object Predicate Lexical cue
T1 0-115 Sentence denotes Disparities in the interaction of rat and human lipoproteins with cultured rat fibroblasts and smooth muscle cells.
T1 0-115 Sentence denotes Disparities in the interaction of rat and human lipoproteins with cultured rat fibroblasts and smooth muscle cells.
T2 116-172 Sentence denotes Requirements for homology for receptor binding activity.
T2 116-172 Sentence denotes Requirements for homology for receptor binding activity.
T3 173-320 Sentence denotes This study characterizes the interactions of various rat and human lipoproteins with the lipoprotein cell surface receptors of rat and human cells.
T3 173-320 Sentence denotes This study characterizes the interactions of various rat and human lipoproteins with the lipoprotein cell surface receptors of rat and human cells.
T4 321-612 Sentence denotes Iodinated rat very low density lipoproteins (VLDL), rat chylomicron remnants, rat low density lipoproteins (LDL), and rat high density lipoproteins containing predominantly apoprotein E (HDL1) bound to high affinity cell surface receptors of cultured rat fibroblasts and smooth muscle cells.
T4 321-612 Sentence denotes Iodinated rat very low density lipoproteins (VLDL), rat chylomicron remnants, rat low density lipoproteins (LDL), and rat high density lipoproteins containing predominantly apoprotein E (HDL1) bound to high affinity cell surface receptors of cultured rat fibroblasts and smooth muscle cells.
T5 613-755 Sentence denotes Rat VLDL and chylomicron remnants were most avidly bound; the B-containing LDL and the E-containing HDL1 displayed lesser but similar binding.
T5 613-755 Sentence denotes Rat VLDL and chylomicron remnants were most avidly bound; the B-containing LDL and the E-containing HDL1 displayed lesser but similar binding.
T6 756-910 Sentence denotes Rat HDL (d = 1.125 to 1.21) exhibited weak receptor binding; however, after recentrifugation to remove apoprotein E, they were devoid of binding activity.
T6 756-910 Sentence denotes Rat HDL (d = 1.125 to 1.21) exhibited weak receptor binding; however, after recentrifugation to remove apoprotein E, they were devoid of binding activity.
T7 911-1244 Sentence denotes Competitive binding studies at 4 degrees C confirmed these results for normal lipoproteins and indicated that VLDL (B-VLDL), LDL, and HDLc (cholesterol-rich HDL1) isolated from hypercholesterolemic rats had increased affinity for the rat receptors compared with their normal counterparts, the most pronounced change being in the LDL.
T7 911-1244 Sentence denotes Competitive binding studies at 4 degrees C confirmed these results for normal lipoproteins and indicated that VLDL (B-VLDL), LDL, and HDLc (cholesterol-rich HDL1) isolated from hypercholesterolemic rats had increased affinity for the rat receptors compared with their normal counterparts, the most pronounced change being in the LDL.
T8 1245-1386 Sentence denotes The cell surface receptor pathway in rat fibroblasts and smooth muscle cells resembled the system described for human fibroblasts as follows:
T8 1245-1386 Sentence denotes The cell surface receptor pathway in rat fibroblasts and smooth muscle cells resembled the system described for human fibroblasts as follows:
T9 1387-1957 Sentence denotes 1) lipoproteins containing either the B or E apoproteins interacted with the receptors; 2) receptor binding activity was abolished by acetoacetylation or reductive methylation of a limited number of lysine residues of the lipoproteins; 3) receptor binding initiated the process of internalization and degradation of the apo-B- and apo-E-containing lipoproteins; 4) the lipoprotein cholesterol was re-esterified as determined by [14C]oleate incorporation into the cellular cholesteryl esters; and 5) receptor-mediated uptake (receptor number) was lipoprotein cholesterol.
T9 1387-1957 Sentence denotes 1) lipoproteins containing either the B or E apoproteins interacted with the receptors; 2) receptor binding activity was abolished by acetoacetylation or reductive methylation of a limited number of lysine residues of the lipoproteins; 3) receptor binding initiated the process of internalization and degradation of the apo-B- and apo-E-containing lipoproteins; 4) the lipoprotein cholesterol was re-esterified as determined by [14C]oleate incorporation into the cellular cholesteryl esters; and 5) receptor-mediated uptake (receptor number) was lipoprotein cholesterol.
T10 1958-2110 Sentence denotes An important difference between rat and human fibroblasts was the inability of human LDL to interact with the cell surface receptors of rat fibroblasts.
T10 1958-2110 Sentence denotes An important difference between rat and human fibroblasts was the inability of human LDL to interact with the cell surface receptors of rat fibroblasts.
T11 2111-2171 Sentence denotes Rat lipoproteins did, however, react with human fibroblasts.
T11 2111-2171 Sentence denotes Rat lipoproteins did, however, react with human fibroblasts.
T12 2172-2268 Sentence denotes Furthermore, the rat VLDL were the most avidly bound of the rat lipoproteins to rat fibroblasts.
T12 2172-2268 Sentence denotes Furthermore, the rat VLDL were the most avidly bound of the rat lipoproteins to rat fibroblasts.
T13 2269-2412 Sentence denotes When the direct binding of 125I-VLDL was subjected to Scatchard analysis, the very high affinity of rat VLDL was apparent (Kd = 1 X 10(-11) M).
T13 2269-2412 Sentence denotes When the direct binding of 125I-VLDL was subjected to Scatchard analysis, the very high affinity of rat VLDL was apparent (Kd = 1 X 10(-11) M).
T14 2413-2537 Sentence denotes Moreover, compared with data for rat LDL, the data suggested each VLDL particle bound to four to nine lipoprotein receptors.
T14 2413-2537 Sentence denotes Moreover, compared with data for rat LDL, the data suggested each VLDL particle bound to four to nine lipoprotein receptors.
T15 2538-2629 Sentence denotes This multiple receptor binding could explain the enhanced binding affinity of the rat VLDL.
T15 2538-2629 Sentence denotes This multiple receptor binding could explain the enhanced binding affinity of the rat VLDL.
T16 2630-2805 Sentence denotes The Scatchard plot of rat 125I-VLDL revealed a biphasic binding curve in rat and human fibroblast cells and in rat smooth muscle cells, suggesting two populations of rat VLDL.
T16 2630-2805 Sentence denotes The Scatchard plot of rat 125I-VLDL revealed a biphasic binding curve in rat and human fibroblast cells and in rat smooth muscle cells, suggesting two populations of rat VLDL.
T17 2806-2935 Sentence denotes These results indicate that rat cells have a receptor pathway similar to, but not identical with, the LDL pathway of human cells.
T17 2806-2935 Sentence denotes These results indicate that rat cells have a receptor pathway similar to, but not identical with, the LDL pathway of human cells.
T18 2936-3121 Sentence denotes Since human LDL bind poorly to rat cell receptors on cultured rat fibroblasts and smooth muscle cells, metabolic studies using human lipoproteins in rats must be interpreted cautiously.
T18 2936-3121 Sentence denotes Since human LDL bind poorly to rat cell receptors on cultured rat fibroblasts and smooth muscle cells, metabolic studies using human lipoproteins in rats must be interpreted cautiously.