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PubMed:6234315 JSONTXT 24 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-95 Sentence denotes Complex formation of platelet membrane glycoproteins IIb and IIIa with the fibrinogen D domain.
T1 0-95 Sentence denotes Complex formation of platelet membrane glycoproteins IIb and IIIa with the fibrinogen D domain.
T2 96-301 Sentence denotes Glycoprotein IIb (GPIIb) and glycoprotein IIIa (GPIIIa) form a macromolecular complex on the activated platelet surface which contains the fibrinogen-binding site necessary for normal platelet aggregation.
T2 96-301 Sentence denotes Glycoprotein IIb (GPIIb) and glycoprotein IIIa (GPIIIa) form a macromolecular complex on the activated platelet surface which contains the fibrinogen-binding site necessary for normal platelet aggregation.
T3 302-553 Sentence denotes To identify the specific region of the fibrinogen molecule responsible for its interaction with the GPIIb-GPIIIa complex, purified fragment D1 (Mr = 100,000) and fragment E (Mr = 50,000) were prepared from plasmin digests of purified human fibrinogen.
T3 302-553 Sentence denotes To identify the specific region of the fibrinogen molecule responsible for its interaction with the GPIIb-GPIIIa complex, purified fragment D1 (Mr = 100,000) and fragment E (Mr = 50,000) were prepared from plasmin digests of purified human fibrinogen.
T4 554-653 Sentence denotes In addition, the polypeptide chain subunits A alpha, B beta, and gamma of fibrinogen were prepared.
T4 554-653 Sentence denotes In addition, the polypeptide chain subunits A alpha, B beta, and gamma of fibrinogen were prepared.
T5 654-819 Sentence denotes Using an enzyme-linked immunosorbent assay we have demonstrated that isolated fragment D1 in a solid phase system forms a complex with a mixture of GPIIb and GPIIIa.
T5 654-819 Sentence denotes Using an enzyme-linked immunosorbent assay we have demonstrated that isolated fragment D1 in a solid phase system forms a complex with a mixture of GPIIb and GPIIIa.
T6 820-957 Sentence denotes The binding of the GPIIb-GPIIIa mixture to fragment D1-coated plates reached saturation at 8 nM and to fibrinogen-coated plates at 24 nM.
T6 820-957 Sentence denotes The binding of the GPIIb-GPIIIa mixture to fragment D1-coated plates reached saturation at 8 nM and to fibrinogen-coated plates at 24 nM.
T7 958-1044 Sentence denotes Isolated A alpha, B beta, and gamma chains were not reactive with added glycoproteins.
T7 958-1044 Sentence denotes Isolated A alpha, B beta, and gamma chains were not reactive with added glycoproteins.
T8 1045-1180 Sentence denotes Fragment E coated directly on plastic plates or immobilized on antibody-coated plastic plates did not form a complex with GPIIb-GPIIIa.
T8 1045-1180 Sentence denotes Fragment E coated directly on plastic plates or immobilized on antibody-coated plastic plates did not form a complex with GPIIb-GPIIIa.
T9 1181-1338 Sentence denotes Only fluid phase fibrinogen and fragment D1 but not fragment E were inhibitory toward formation of a complex between solid phase fibrinogen and GPIIb-GPIIIa.
T9 1181-1338 Sentence denotes Only fluid phase fibrinogen and fragment D1 but not fragment E were inhibitory toward formation of a complex between solid phase fibrinogen and GPIIb-GPIIIa.
T10 1339-1451 Sentence denotes Isolated A alpha, B beta, and gamma chains at concentrations equivalent to fluid phase fibrinogen were inactive.
T10 1339-1451 Sentence denotes Isolated A alpha, B beta, and gamma chains at concentrations equivalent to fluid phase fibrinogen were inactive.
T11 1452-1752 Sentence denotes Binding of fragment D1 but not fragment E to the GPIIb-GPIIIa complex was also demonstrated by rocket immunoelectrophoresis of the membrane glycoprotein mixture through a gel containing the individual fragments and subsequent autoradiography of the complex following exposure to 125I-anti-fibrinogen.
T11 1452-1752 Sentence denotes Binding of fragment D1 but not fragment E to the GPIIb-GPIIIa complex was also demonstrated by rocket immunoelectrophoresis of the membrane glycoprotein mixture through a gel containing the individual fragments and subsequent autoradiography of the complex following exposure to 125I-anti-fibrinogen.
T12 1753-2092 Sentence denotes These observations with isolated platelet membrane glycoproteins provide strong evidence that each of the D domains of the fibrinogen molecule interacts directly with the GPIIb-GPIIIa complex on the activated platelet surface, thus allowing formation of a tertiary molecular "bridge" across the surface of two adjacent activated platelets.
T12 1753-2092 Sentence denotes These observations with isolated platelet membrane glycoproteins provide strong evidence that each of the D domains of the fibrinogen molecule interacts directly with the GPIIb-GPIIIa complex on the activated platelet surface, thus allowing formation of a tertiary molecular "bridge" across the surface of two adjacent activated platelets.