| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-148 |
Sentence |
denotes |
Effects of hydrogen peroxide on basal and hormone-stimulated lipolysis in perifused rat fat cells in relation to the mechanism of action of insulin. |
| T1 |
0-148 |
Sentence |
denotes |
Effects of hydrogen peroxide on basal and hormone-stimulated lipolysis in perifused rat fat cells in relation to the mechanism of action of insulin. |
| T2 |
149-392 |
Sentence |
denotes |
Since insulin is known to stimulate intracellular hydrogen peroxide production in rat epididymal fat cells, the effects of exogenous hydrogen peroxide on rates of basal and hormone-stimulated lipolysis were investigated in a perifusion system. |
| T2 |
149-392 |
Sentence |
denotes |
Since insulin is known to stimulate intracellular hydrogen peroxide production in rat epididymal fat cells, the effects of exogenous hydrogen peroxide on rates of basal and hormone-stimulated lipolysis were investigated in a perifusion system. |
| T3 |
393-544 |
Sentence |
denotes |
H2O2 (60 microM) caused a weak and transient stimulation of basal lipolysis that did not interfere with subsequent activation of lipolysis by hormones. |
| T3 |
393-544 |
Sentence |
denotes |
H2O2 (60 microM) caused a weak and transient stimulation of basal lipolysis that did not interfere with subsequent activation of lipolysis by hormones. |
| T4 |
545-754 |
Sentence |
denotes |
More importantly, lipolysis stimulated submaximally with ritodrine (10(-7) M) or glucagon (10(-9) M) was inhibited by H2O2 in a manner similar to insulin, although slight differences in time course were noted. |
| T4 |
545-754 |
Sentence |
denotes |
More importantly, lipolysis stimulated submaximally with ritodrine (10(-7) M) or glucagon (10(-9) M) was inhibited by H2O2 in a manner similar to insulin, although slight differences in time course were noted. |
| T5 |
755-844 |
Sentence |
denotes |
Ritodrine served as a beta-adrenergic agonist resistant to oxidative destruction by H2O2. |
| T5 |
755-844 |
Sentence |
denotes |
Ritodrine served as a beta-adrenergic agonist resistant to oxidative destruction by H2O2. |
| T6 |
845-927 |
Sentence |
denotes |
The inhibition of lipolysis was reversible upon cessation of perifusion with H2O2. |
| T6 |
845-927 |
Sentence |
denotes |
The inhibition of lipolysis was reversible upon cessation of perifusion with H2O2. |
| T7 |
928-1057 |
Sentence |
denotes |
These findings ruled out oxidative destruction of the hormone or cell death as explanations for the antilipolytic effect of H2O2. |
| T7 |
928-1057 |
Sentence |
denotes |
These findings ruled out oxidative destruction of the hormone or cell death as explanations for the antilipolytic effect of H2O2. |
| T8 |
1058-1267 |
Sentence |
denotes |
Like insulin, H2O2 also inhibited 1-methyl-3-isobutylxanthine (4 X 10(-6) M)-stimulated lipolysis, but whereas insulin inhibited lipolysis stimulated by dibutyryl-cAMP (4 X 10(-4) M), H2O2 further enhanced it. |
| T8 |
1058-1267 |
Sentence |
denotes |
Like insulin, H2O2 also inhibited 1-methyl-3-isobutylxanthine (4 X 10(-6) M)-stimulated lipolysis, but whereas insulin inhibited lipolysis stimulated by dibutyryl-cAMP (4 X 10(-4) M), H2O2 further enhanced it. |
| T9 |
1268-1477 |
Sentence |
denotes |
These findings add another case to the growing list of insulin effects on adipocytes that can be mimicked by exogenous H2O2, and they hint at a site where the mechanisms of action of the two agents may differ. |
| T9 |
1268-1477 |
Sentence |
denotes |
These findings add another case to the growing list of insulin effects on adipocytes that can be mimicked by exogenous H2O2, and they hint at a site where the mechanisms of action of the two agents may differ. |