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PubMed:523196 JSONTXT 15 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-125 Sentence denotes Utilization of purines by an HPRT variant in an intelligent, nonmutilative patient with features of the Lesch-Nyhan syndrome.
T1 0-125 Sentence denotes Utilization of purines by an HPRT variant in an intelligent, nonmutilative patient with features of the Lesch-Nyhan syndrome.
TextSentencer_T2 126-233 Sentence denotes The patient, H.Chr.B., was among the first reported with hyperuricemia and central nervous system symptoms.
T2 126-233 Sentence denotes The patient, H.Chr.B., was among the first reported with hyperuricemia and central nervous system symptoms.
TextSentencer_T3 234-416 Sentence denotes He has been found to have a variant of hypoxanthine guanine phosphoribosyl transferase (HPRT; E.C.2.4.2.8) distinct from the enzyme present in patients with the Lesch-Nyhan syndrome.
T3 234-416 Sentence denotes He has been found to have a variant of hypoxanthine guanine phosphoribosyl transferase (HPRT; E.C.2.4.2.8) distinct from the enzyme present in patients with the Lesch-Nyhan syndrome.
TextSentencer_T4 417-499 Sentence denotes The patient had chroeoathetosis, spasticity, dysarthric speech, and hyperuricemia.
T4 417-499 Sentence denotes The patient had chroeoathetosis, spasticity, dysarthric speech, and hyperuricemia.
TextSentencer_T5 500-579 Sentence denotes However, his intelligence was normal and he had no evidence of self-mutilation.
T5 500-579 Sentence denotes However, his intelligence was normal and he had no evidence of self-mutilation.
TextSentencer_T6 580-700 Sentence denotes There was no activity of HPRT in the lysates of erythrocytes and cultured fibroblasts when analyzed in the usual manner.
T6 580-700 Sentence denotes There was no activity of HPRT in the lysates of erythrocytes and cultured fibroblasts when analyzed in the usual manner.
TextSentencer_T7 701-942 Sentence denotes Using a newly developed method for the study of purine metabolism in intact cultured cells, this patient was found to metabolize some 9% of 8-14C-hypoxanthine, and 90% of the isotope utilized was converted to adenine and guanine nucleotides.
T7 701-942 Sentence denotes Using a newly developed method for the study of purine metabolism in intact cultured cells, this patient was found to metabolize some 9% of 8-14C-hypoxanthine, and 90% of the isotope utilized was converted to adenine and guanine nucleotides.
TextSentencer_T8 943-1078 Sentence denotes In contrast, cells from patients with the Lesch-Nyhan syndrome were virtually completely unable to convert hypoxanthine to nucleotides.
T8 943-1078 Sentence denotes In contrast, cells from patients with the Lesch-Nyhan syndrome were virtually completely unable to convert hypoxanthine to nucleotides.
TextSentencer_T9 1079-1274 Sentence denotes The patient's fibroblasts were even more efficient in the metabolism of 8-14C-guanine, which was utilized to the extent of 27%, over 80% of which was converted to guanine and adenine nucleotides.
T9 1079-1274 Sentence denotes The patient's fibroblasts were even more efficient in the metabolism of 8-14C-guanine, which was utilized to the extent of 27%, over 80% of which was converted to guanine and adenine nucleotides.
TextSentencer_T10 1275-1494 Sentence denotes The growth of the cultured fibroblasts of this patient was intermediate in media containing hypoxanthine aminopterin thymidine (HAT), whereas the growth of Lesch-Nyhan cells was inhibited and normal cells grew normally.
T10 1275-1494 Sentence denotes The growth of the cultured fibroblasts of this patient was intermediate in media containing hypoxanthine aminopterin thymidine (HAT), whereas the growth of Lesch-Nyhan cells was inhibited and normal cells grew normally.
TextSentencer_T11 1495-1648 Sentence denotes Similarly in 8-azaguanine, 6-thioguanine, and 8-azahypoxanthine, the growth of the patient's cells was intermediate between normal and Lesch-Nyhan cells.
T11 1495-1648 Sentence denotes Similarly in 8-azaguanine, 6-thioguanine, and 8-azahypoxanthine, the growth of the patient's cells was intermediate between normal and Lesch-Nyhan cells.
TextSentencer_T12 1649-1794 Sentence denotes These observations provide further evidence for genetic heterogeneity among patients with disorders in purine metabolism involving the HPRT gene.
T12 1649-1794 Sentence denotes These observations provide further evidence for genetic heterogeneity among patients with disorders in purine metabolism involving the HPRT gene.
TextSentencer_T13 1795-1872 Sentence denotes They document that this famous patient did not have the Lesch-Nyhan syndrome.
T13 1795-1872 Sentence denotes They document that this famous patient did not have the Lesch-Nyhan syndrome.