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PubMed:3597414 JSONTXT 23 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-129 Sentence denotes Purification of catalytic subunit of low density lipoprotein receptor kinase and identification of heat-stable activator protein.
T1 0-129 Sentence denotes Purification of catalytic subunit of low density lipoprotein receptor kinase and identification of heat-stable activator protein.
T2 130-370 Sentence denotes Bovine adrenal cortex contains a high molecular weight casein kinase II-like enzyme (Mr 500,000) that phosphorylates a specific serine residue in the cytoplasmic domain of the low density lipoprotein (LDL) receptor (Kishimoto, A., Brown, M.
T2 130-370 Sentence denotes Bovine adrenal cortex contains a high molecular weight casein kinase II-like enzyme (Mr 500,000) that phosphorylates a specific serine residue in the cytoplasmic domain of the low density lipoprotein (LDL) receptor (Kishimoto, A., Brown, M.
T3 371-388 Sentence denotes S., Slaughter, C.
T3 371-388 Sentence denotes S., Slaughter, C.
T4 389-410 Sentence denotes A., and Goldstein, J.
T4 389-410 Sentence denotes A., and Goldstein, J.
T5 411-428 Sentence denotes L. (1987) J Biol.
T5 411-428 Sentence denotes L. (1987) J Biol.
T6 429-434 Sentence denotes Chem.
T6 429-434 Sentence denotes Chem.
T7 435-451 Sentence denotes 262, 1344-1351).
T7 435-451 Sentence denotes 262, 1344-1351).
T8 452-641 Sentence denotes In the current paper, we provide evidence to suggest that this 500-kDa kinase can be dissociated into two subunits, a catalytic subunit and an activator subunit, by treatment with 1 M NaCl.
T8 452-641 Sentence denotes In the current paper, we provide evidence to suggest that this 500-kDa kinase can be dissociated into two subunits, a catalytic subunit and an activator subunit, by treatment with 1 M NaCl.
T9 642-805 Sentence denotes The catalytic subunit was purified to homogeneity (greater than 100,000-fold) using affinity chromatography on GTP-agarose plus several other chromatography steps.
T9 642-805 Sentence denotes The catalytic subunit was purified to homogeneity (greater than 100,000-fold) using affinity chromatography on GTP-agarose plus several other chromatography steps.
T10 806-922 Sentence denotes It had an Mr of 50,000 by gel filtration and 35,000 by polyacrylamide gel electrophoresis in sodium dodecyl sulfate.
T10 806-922 Sentence denotes It had an Mr of 50,000 by gel filtration and 35,000 by polyacrylamide gel electrophoresis in sodium dodecyl sulfate.
T11 923-1039 Sentence denotes The catalytic subunit phosphorylated casein actively, but it phosphorylated the LDL receptor with only low affinity.
T11 923-1039 Sentence denotes The catalytic subunit phosphorylated casein actively, but it phosphorylated the LDL receptor with only low affinity.
T12 1040-1238 Sentence denotes The affinity for the LDL receptor was increased 10-fold (saturation at 10 nM LDL receptor) by addition of a second protein that was released from a high molecular weight 500-kDa complex by 1 M NaCl.
T12 1040-1238 Sentence denotes The affinity for the LDL receptor was increased 10-fold (saturation at 10 nM LDL receptor) by addition of a second protein that was released from a high molecular weight 500-kDa complex by 1 M NaCl.
T13 1239-1348 Sentence denotes This activator protein (Mr 120,000 by gel filtration) was extremely heat stable but was destroyed by trypsin.
T13 1239-1348 Sentence denotes This activator protein (Mr 120,000 by gel filtration) was extremely heat stable but was destroyed by trypsin.
T14 1349-1436 Sentence denotes It appeared to be required in stoichiometric amounts with relation to the LDL receptor.
T14 1349-1436 Sentence denotes It appeared to be required in stoichiometric amounts with relation to the LDL receptor.
T15 1437-1609 Sentence denotes It did not increase the ability of the 50-kDa subunit to phosphorylate casein nor did it activate phosphorylation of the LDL receptor or casein by classic casein kinase II.
T15 1437-1609 Sentence denotes It did not increase the ability of the 50-kDa subunit to phosphorylate casein nor did it activate phosphorylation of the LDL receptor or casein by classic casein kinase II.
T16 1610-1869 Sentence denotes The current data raise the possibility that the specificity of the 500-kDa LDL receptor kinase is attributable to a heat-stable activator subunit that binds to the LDL receptor and thereby renders it a better substrate for the catalytic subunit of the kinase.
T16 1610-1869 Sentence denotes The current data raise the possibility that the specificity of the 500-kDa LDL receptor kinase is attributable to a heat-stable activator subunit that binds to the LDL receptor and thereby renders it a better substrate for the catalytic subunit of the kinase.