| Id |
Subject |
Object |
Predicate |
Lexical cue |
| TextSentencer_T1 |
0-130 |
Sentence |
denotes |
The conformation of glycans of the oligo-D-mannosidic type, and their interaction with concanavalin A: a computer-modelling study. |
| T1 |
0-130 |
Sentence |
denotes |
The conformation of glycans of the oligo-D-mannosidic type, and their interaction with concanavalin A: a computer-modelling study. |
| TextSentencer_T2 |
131-259 |
Sentence |
denotes |
The favored conformations of glycans of the oligo-D-mannosidic type have been determined by using empirical energy calculations. |
| T2 |
131-259 |
Sentence |
denotes |
The favored conformations of glycans of the oligo-D-mannosidic type have been determined by using empirical energy calculations. |
| TextSentencer_T3 |
260-505 |
Sentence |
denotes |
An interesting aspect is that the alpha-(1----3)-linked terminal D-mannose residue of the outer trimannosidic core fragment, in all the conformations which fall within 5 kcal.mol-1 of the global minimum, always lies close to the chitobiose core. |
| T3 |
260-505 |
Sentence |
denotes |
An interesting aspect is that the alpha-(1----3)-linked terminal D-mannose residue of the outer trimannosidic core fragment, in all the conformations which fall within 5 kcal.mol-1 of the global minimum, always lies close to the chitobiose core. |
| TextSentencer_T4 |
506-575 |
Sentence |
denotes |
These models are in general agreement with the available n.m.r. data. |
| T4 |
506-575 |
Sentence |
denotes |
These models are in general agreement with the available n.m.r. data. |
| TextSentencer_T5 |
576-855 |
Sentence |
denotes |
The probable modes of binding of these glycans to concanavalin A (Con A) were determined, by using a computer-modelling technique which identifies the positions for the different conformers of the carbohydrate in the binding site of Con A, based on stereochemical considerations. |
| T5 |
576-855 |
Sentence |
denotes |
The probable modes of binding of these glycans to concanavalin A (Con A) were determined, by using a computer-modelling technique which identifies the positions for the different conformers of the carbohydrate in the binding site of Con A, based on stereochemical considerations. |
| TextSentencer_T6 |
856-1079 |
Sentence |
denotes |
These studies showed that Con A can bind only to two of the three terminal D-mannose residues in these glycans, because the D-mannose residue which lies close to the chitobiose core is inaccessible for the binding of Con A. |
| T6 |
856-1079 |
Sentence |
denotes |
These studies showed that Con A can bind only to two of the three terminal D-mannose residues in these glycans, because the D-mannose residue which lies close to the chitobiose core is inaccessible for the binding of Con A. |
| TextSentencer_T7 |
1080-1185 |
Sentence |
denotes |
Of these two terminal D-mannose residues, the alpha-(1----6)-linked D-mannose may bind the more strongly. |
| T7 |
1080-1185 |
Sentence |
denotes |
Of these two terminal D-mannose residues, the alpha-(1----6)-linked D-mannose may bind the more strongly. |
| TextSentencer_T8 |
1186-1327 |
Sentence |
denotes |
Furthermore, it is shown that the internal D-mannose residue will, at best, interact very weakly with the carbohydrate-binding site of Con A. |
| T8 |
1186-1327 |
Sentence |
denotes |
Furthermore, it is shown that the internal D-mannose residue will, at best, interact very weakly with the carbohydrate-binding site of Con A. |
| TextSentencer_T9 |
1328-1428 |
Sentence |
denotes |
These results rationalize well the available data on the binding affinity of these glycans to Con A. |
| T9 |
1328-1428 |
Sentence |
denotes |
These results rationalize well the available data on the binding affinity of these glycans to Con A. |
| TextSentencer_T10 |
1429-1690 |
Sentence |
denotes |
They further support the conclusion that the binding affinity of a glycan to Con A does not depend on the number in the glycan, of D-mannose residues which possess free 3-, 4-, and 6-hydroxyl groups, but, rather, on the accessibility of these residues to Con A. |
| T10 |
1429-1690 |
Sentence |
denotes |
They further support the conclusion that the binding affinity of a glycan to Con A does not depend on the number in the glycan, of D-mannose residues which possess free 3-, 4-, and 6-hydroxyl groups, but, rather, on the accessibility of these residues to Con A. |