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PubMed:34146542 JSONTXT 36 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-107 Sentence denotes Trefoil factor 2 secreted from damaged hepatocytes activates hepatic stellate cells to induce fibrogenesis.
T1 0-107 Sentence denotes Trefoil factor 2 secreted from damaged hepatocytes activates hepatic stellate cells to induce fibrogenesis.
T2 108-176 Sentence denotes Liver fibrosis is a common characteristic of chronic liver diseases.
T2 108-176 Sentence denotes Liver fibrosis is a common characteristic of chronic liver diseases.
T3 177-387 Sentence denotes The activation of hepatic stellate cells (HSCs) plays a key role in fibrogenesis in response to liver injury, yet the mechanism by which damaged hepatocytes modulate the activation of HSCs is poorly understood.
T3 177-387 Sentence denotes The activation of hepatic stellate cells (HSCs) plays a key role in fibrogenesis in response to liver injury, yet the mechanism by which damaged hepatocytes modulate the activation of HSCs is poorly understood.
T4 388-541 Sentence denotes Our previous studies have established that liver-specific deletion of O-GlcNAc transferase (OGT)leads to hepatocyte necroptosis and spontaneous fibrosis.
T4 388-541 Sentence denotes Our previous studies have established that liver-specific deletion of O-GlcNAc transferase (OGT)leads to hepatocyte necroptosis and spontaneous fibrosis.
T5 542-683 Sentence denotes Here, we report that OGT-deficient hepatocytes secrete trefoil factor 2 (TFF2) that activates HSCs and contributes to the fibrogenic process.
T5 542-683 Sentence denotes Here, we report that OGT-deficient hepatocytes secrete trefoil factor 2 (TFF2) that activates HSCs and contributes to the fibrogenic process.
T6 684-788 Sentence denotes The expression and secretion of TFF2 are induced in OGT-deficient hepatocytes but not in WT hepatocytes.
T6 684-788 Sentence denotes The expression and secretion of TFF2 are induced in OGT-deficient hepatocytes but not in WT hepatocytes.
T7 789-933 Sentence denotes TFF2 activates the platelet-derived growth factor receptor beta signaling pathway that promotes the proliferation and migration of primary HSCs.
T7 789-933 Sentence denotes TFF2 activates the platelet-derived growth factor receptor beta signaling pathway that promotes the proliferation and migration of primary HSCs.
T8 934-1025 Sentence denotes TFF2 protein expression is elevated in mice with carbon tetrachloride-induced liver injury.
T8 934-1025 Sentence denotes TFF2 protein expression is elevated in mice with carbon tetrachloride-induced liver injury.
T9 1026-1219 Sentence denotes These findings identify TFF2 as a novel factor that mediates intercellular signaling between hepatocytes and HSCs and suggest a role of the hepatic OGT-TFF2 axis in the process of fibrogenesis.
T9 1026-1219 Sentence denotes These findings identify TFF2 as a novel factor that mediates intercellular signaling between hepatocytes and HSCs and suggest a role of the hepatic OGT-TFF2 axis in the process of fibrogenesis.