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PubMed:33038510 JSONTXT 35 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-142 Sentence denotes Microfibril associated protein 4 (MFAP4) is a carrier of the tumor associated carbohydrate sialyl-Lewis x (sLex) in pancreatic adenocarcinoma.
T2 143-379 Sentence denotes Late diagnosis of pancreatic ductal adenocarcinoma (PDA) is one of the reasons of its low 5-year survival rate and it is due to its unspecific symptoms during the first stages of the disease and the lack of reliable serological markers.
T3 380-613 Sentence denotes Since PDA shows an altered glycan expression, here we have focused on finding novel potential biomarkers, namely glycoproteins that express the tumor associated carbohydrate structure sialyl-Lewis x (sLex), which is described in PDA.
T4 614-841 Sentence denotes Through a glycoproteomic approach, we have analyzed target proteins containing sLex from PDA tissues by 2DE and immunodetection techniques, and have identified by mass spectrometry the protein MFAP4 as a carrier of sLex in PDA.
T5 842-931 Sentence denotes MFAP4 showed a higher expression in PDA tissues compared with pancreatic control tissues.
T6 932-1043 Sentence denotes In addition, the colocalization of sLex over MFAP4 was found only in PDA and not in control pancreatic tissues.
T7 1044-1287 Sentence denotes The analysis of MFAP4 expression in PDA cell lines and their secretome, in combination with immunohistochemistry of pancreatic tissues, revealed that MFAP4 was not produced by PDA cells, but it was found in the pancreatic extracellular matrix.
T8 1288-1403 Sentence denotes The specificity of MFAP4 glycoform containing sLex in PDA tissues shows its relevance as a potential PDA biomarker.
T9 1404-1417 Sentence denotes SIGNIFICANCE:
T10 1418-1642 Sentence denotes Despite advances in the field of cancer research, pancreatic ductal adenocarcinoma (PDA) lacks of a specific and sensitive biomarker for its early detection, when curative resection is still possible before metastases arise.
T11 1643-1789 Sentence denotes Thus, efforts to discover new PDA biomarkers represent the first line in the fight against the increase of its incidence reported in recent years.
T12 1790-1928 Sentence denotes Glycan alterations on glycoconjugates, such as glycoproteins have emerged as a rich source for the identification of novel cancer markers.
T13 1929-2143 Sentence denotes In the present work, we aimed to shed light on novel biomarkers based on altered glycosylation in PDA, in particular those glycoproteins of PDA tissues carrying the tumor carbohydrate antigen sialyl-Lewis x (sLex).
T14 2144-2287 Sentence denotes Through a glycoproteomic approach, we have shown that the glycoprotein MFAP4 carries sLex in PDA tissues and not in control pancreatic tissues.
T15 2288-2480 Sentence denotes MFAP4 is found in the extracellular matrix in PDA and although its role in cancer progression is unclear, its sLex glycoform could be a potential biomarker in pancreatic ductal adenocarcinoma.