| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-107 |
Sentence |
denotes |
Structure, Dynamics, and Interactions of GPI-Anchored Human Glypican-1 with Heparan Sulfates in a Membrane. |
| T2 |
108-250 |
Sentence |
denotes |
Glypican-1 and its heparan sulfate (HS) chains play important roles in modulating many biological processes including growth factor signaling. |
| T3 |
251-341 |
Sentence |
denotes |
Glypican-1 is bound to a membrane surface via a glycosylphosphatidylinositol (GPI)-anchor. |
| T4 |
342-526 |
Sentence |
denotes |
In this study, we used all-atom molecular modeling and simulation to explore the structure, dynamics, and interactions of GPI-anchored glypican-1, three HS chains, membranes, and ions. |
| T5 |
527-762 |
Sentence |
denotes |
The folded glypican-1 core structure is stable, but has substantial degrees of freedom in terms of movement and orientation with respect to the membrane due to the long unstructured C-terminal region linking the core to the GPI-anchor. |
| T6 |
763-954 |
Sentence |
denotes |
With unique structural features depending on the extent of sulfation, high flexibility of HS chains can promote multi-site interactions with surrounding molecules near and above the membrane. |
| T7 |
955-1136 |
Sentence |
denotes |
This study is a first step toward all-atom molecular modeling and simulation of the glycocalyx, as well as its modulation of interactions between growth factors and their receptors. |
