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PubMed:32985653 JSONTXT 21 Projects

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Id Subject Object Predicate Lexical cue
T1 0-84 Sentence denotes The iminosugars celgosivir, castanospermine and UV-4 inhibit SARS-CoV-2 replication.
T1 0-84 Sentence denotes The iminosugars celgosivir, castanospermine and UV-4 inhibit SARS-CoV-2 replication.
T2 85-230 Sentence denotes The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic poses an unprecedented challenge for healthcare and the global economy.
T2 85-230 Sentence denotes The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic poses an unprecedented challenge for healthcare and the global economy.
T3 231-382 Sentence denotes Repurposing drugs that have shown promise in inhibiting other viral infections could allow for more rapid dispensation of urgently needed therapeutics.
T3 231-382 Sentence denotes Repurposing drugs that have shown promise in inhibiting other viral infections could allow for more rapid dispensation of urgently needed therapeutics.
T4 383-507 Sentence denotes The Spike protein of SARS-CoV-2 is extensively glycosylated with 22 occupied N glycan sites and is required for viral entry.
T4 383-507 Sentence denotes The Spike protein of SARS-CoV-2 is extensively glycosylated with 22 occupied N glycan sites and is required for viral entry.
T5 508-767 Sentence denotes In other glycosylated viral proteins, glycosylation is required for interaction with calnexin and chaperone-mediated folding in the endoplasmic reticulum, and prevention of this interaction leads to unfolded viral proteins and thus inhibits viral replication.
T5 508-767 Sentence denotes In other glycosylated viral proteins, glycosylation is required for interaction with calnexin and chaperone-mediated folding in the endoplasmic reticulum, and prevention of this interaction leads to unfolded viral proteins and thus inhibits viral replication.
T6 768-935 Sentence denotes As such, we investigated two iminosugars, celgosivir, a pro-drug of castanospermine, and UV-4, or N-(9-methoxynonyl)-1-deoxynojirimycin, a deoxynojirimycin derivative.
T6 768-935 Sentence denotes As such, we investigated two iminosugars, celgosivir, a pro-drug of castanospermine, and UV-4, or N-(9-methoxynonyl)-1-deoxynojirimycin, a deoxynojirimycin derivative.
T7 936-1104 Sentence denotes Iminosugars are known inhibitors of the α-glucosidase I and II enzymes and were effective at inhibiting authentic SARS-CoV-2 viral replication in a cell culture system.
T7 936-1104 Sentence denotes Iminosugars are known inhibitors of the α-glucosidase I and II enzymes and were effective at inhibiting authentic SARS-CoV-2 viral replication in a cell culture system.
T8 1105-1268 Sentence denotes Celgosivir prevented SARS-CoV-2-induced cell death and reduced viral replication and Spike protein levels in a dose-dependent manner in culture with Vero E6 cells.
T8 1105-1268 Sentence denotes Celgosivir prevented SARS-CoV-2-induced cell death and reduced viral replication and Spike protein levels in a dose-dependent manner in culture with Vero E6 cells.
T9 1269-1429 Sentence denotes Castanospermine, the active form of celgosivir, was also able to inhibit SARS-CoV-2, confirming the canonical castanospermine mechanism of action of celgosivir.
T9 1269-1429 Sentence denotes Castanospermine, the active form of celgosivir, was also able to inhibit SARS-CoV-2, confirming the canonical castanospermine mechanism of action of celgosivir.
T10 1430-1612 Sentence denotes The monocyclic UV-4 also prevented SARS-CoV-2-induced death and reduced viral replication after 24 hours of treatment, although the reduction in viral copies was lost after 48 hours.
T10 1430-1612 Sentence denotes The monocyclic UV-4 also prevented SARS-CoV-2-induced death and reduced viral replication after 24 hours of treatment, although the reduction in viral copies was lost after 48 hours.
T11 1613-1718 Sentence denotes Our findings suggest that iminosugars should be urgently investigated as potential SARS-CoV-2 inhibitors.
T11 1613-1718 Sentence denotes Our findings suggest that iminosugars should be urgently investigated as potential SARS-CoV-2 inhibitors.