| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-139 |
Sentence |
denotes |
Impaired NLRP3 inflammasome activation/pyroptosis leads to robust inflammatory cell death via caspase-8/RIPK3 during coronavirus infection. |
| T2 |
140-275 |
Sentence |
denotes |
Coronaviruses have caused several zoonotic infections in the past two decades, leading to significant morbidity and mortality globally. |
| T3 |
276-496 |
Sentence |
denotes |
Balanced regulation of cell death and inflammatory immune responses is essential to promote protection against coronavirus infection; however, the underlying mechanisms that control these processes remain to be resolved. |
| T4 |
497-675 |
Sentence |
denotes |
Here we demonstrate that infection with the murine coronavirus mouse hepatitis virus (MHV) activated the NLRP3 inflammasome and inflammatory cell death in the form of PANoptosis. |
| T5 |
676-1007 |
Sentence |
denotes |
Deleting NLRP3 inflammasome components or the downstream cell death executioner gasdermin D (GSDMD) led to an initial reduction in cell death followed by a robust increase in the incidence of caspase-8- and receptor-interacting serine/threonine-protein kinase 3 (RIPK3)-mediated inflammatory cell death after coronavirus infection. |
| T6 |
1008-1082 |
Sentence |
denotes |
Additionally, loss of GSDMD promoted robust NLRP3 inflammasome activation. |
| T7 |
1083-1216 |
Sentence |
denotes |
Moreover, the amounts of some cytokines released during coronavirus infection were significantly altered due to the absence of GSDMD. |
| T8 |
1217-1418 |
Sentence |
denotes |
Altogether our findings show that inflammatory cell death is induced by coronavirus infection and that impaired NLRP3 inflammasome function or pyroptosis can lead to negative consequences for the host. |
| T9 |
1419-1509 |
Sentence |
denotes |
These findings may have important implications for studies of coronavirus-induced disease. |
