Id |
Subject |
Object |
Predicate |
Lexical cue |
T1 |
0-78 |
Sentence |
denotes |
Repurpose Open Data to Discover Therapeutics for COVID-19 Using Deep Learning. |
T1 |
0-78 |
Sentence |
denotes |
Repurpose Open Data to Discover Therapeutics for COVID-19 Using Deep Learning. |
T2 |
79-325 |
Sentence |
denotes |
There have been more than 2.2 million confirmed cases and over 120 000 deaths from the human coronavirus disease 2019 (COVID-19) pandemic, caused by the novel severe acute respiratory syndrome coronavirus (SARS-CoV-2), in the United States alone. |
T2 |
79-325 |
Sentence |
denotes |
There have been more than 2.2 million confirmed cases and over 120 000 deaths from the human coronavirus disease 2019 (COVID-19) pandemic, caused by the novel severe acute respiratory syndrome coronavirus (SARS-CoV-2), in the United States alone. |
T3 |
326-410 |
Sentence |
denotes |
However, there is currently a lack of proven effective medications against COVID-19. |
T3 |
326-410 |
Sentence |
denotes |
However, there is currently a lack of proven effective medications against COVID-19. |
T4 |
411-525 |
Sentence |
denotes |
Drug repurposing offers a promising route for the development of prevention and treatment strategies for COVID-19. |
T4 |
411-525 |
Sentence |
denotes |
Drug repurposing offers a promising route for the development of prevention and treatment strategies for COVID-19. |
T5 |
526-662 |
Sentence |
denotes |
This study reports an integrative, network-based deep-learning methodology to identify repurposable drugs for COVID-19 (termed CoV-KGE). |
T5 |
526-662 |
Sentence |
denotes |
This study reports an integrative, network-based deep-learning methodology to identify repurposable drugs for COVID-19 (termed CoV-KGE). |
T6 |
663-916 |
Sentence |
denotes |
Specifically, we built a comprehensive knowledge graph that includes 15 million edges across 39 types of relationships connecting drugs, diseases, proteins/genes, pathways, and expression from a large scientific corpus of 24 million PubMed publications. |
T6 |
663-916 |
Sentence |
denotes |
Specifically, we built a comprehensive knowledge graph that includes 15 million edges across 39 types of relationships connecting drugs, diseases, proteins/genes, pathways, and expression from a large scientific corpus of 24 million PubMed publications. |
T7 |
917-1278 |
Sentence |
denotes |
Using Amazon's AWS computing resources and a network-based, deep-learning framework, we identified 41 repurposable drugs (including dexamethasone, indomethacin, niclosamide, and toremifene) whose therapeutic associations with COVID-19 were validated by transcriptomic and proteomics data in SARS-CoV-2-infected human cells and data from ongoing clinical trials. |
T7 |
917-1278 |
Sentence |
denotes |
Using Amazon's AWS computing resources and a network-based, deep-learning framework, we identified 41 repurposable drugs (including dexamethasone, indomethacin, niclosamide, and toremifene) whose therapeutic associations with COVID-19 were validated by transcriptomic and proteomics data in SARS-CoV-2-infected human cells and data from ongoing clinical trials. |
T8 |
1279-1523 |
Sentence |
denotes |
Whereas this study by no means recommends specific drugs, it demonstrates a powerful deep-learning methodology to prioritize existing drugs for further investigation, which holds the potential to accelerate therapeutic development for COVID-19. |
T8 |
1279-1523 |
Sentence |
denotes |
Whereas this study by no means recommends specific drugs, it demonstrates a powerful deep-learning methodology to prioritize existing drugs for further investigation, which holds the potential to accelerate therapeutic development for COVID-19. |