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Id Subject Object Predicate Lexical cue
T1 0-123 Sentence denotes Structural and functional conservation of the programmed -1 ribosomal frameshift signal of SARS coronavirus 2 (SARS-CoV-2).
T2 124-310 Sentence denotes About 17 years after the severe acute respiratory syndrome coronavirus (SARS-CoV) epidemic, the world is currently facing the COVID-19 pandemic caused by SARS coronavirus 2 (SARS-CoV-2).
T3 311-526 Sentence denotes According to the most optimistic projections, it will take more than a year to develop a vaccine, so the best short-term strategy may lie in identifying virus-specific targets for small molecule-based interventions.
T4 527-679 Sentence denotes All coronaviruses utilize a molecular mechanism called programmed -1 ribosomal frameshift (-1 PRF) to control the relative expression of their proteins.
T5 680-880 Sentence denotes Previous analyses of SARS-CoV have revealed that it employs a structurally unique three-stemmed mRNA pseudoknot that stimulates high -1 PRF rates and that it also harbors a -1 PRF attenuation element.
T6 881-995 Sentence denotes Altering -1 PRF activity impairs virus replication, suggesting that this activity may be therapeutically targeted.
T7 996-1075 Sentence denotes Here, we comparatively analyzed the SARS-CoV and SARS-CoV-2 frameshift signals.
T8 1076-1296 Sentence denotes Structural and functional analyses revealed that both elements promote similar -1 PRF rates and that silent coding mutations in the slippery sites and in all three stems of the pseudoknot strongly ablate -1 PRF activity.
T9 1297-1458 Sentence denotes We noted that the upstream attenuator hairpin activity is also functionally retained in both viruses, despite differences in the primary sequence in this region.
T10 1459-1582 Sentence denotes Small-angle X-ray scattering analyses indicated that the pseudoknots in SARS-CoV and SARS-CoV-2 have the same conformation.
T11 1583-1846 Sentence denotes Finally, a small molecule previously shown to bind the SARS-CoV pseudoknot and inhibit -1 PRF was similarly effective against -1 PRF in SARS-CoV-2, suggesting that such frameshift inhibitors may be promising lead compounds to combat the current COVID-19 pandemic.