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Id Subject Object Predicate Lexical cue
T1 0-95 Sentence denotes Determination of globotriaosylceramide analogs in the organs of a mouse model of Fabry disease.
T1 0-95 Sentence denotes Determination of globotriaosylceramide analogs in the organs of a mouse model of Fabry disease.
T2 96-266 Sentence denotes Fabry disease is a heritable lipid disorder caused by the low activity of α-galactosidase A and characterized by the systemic accumulation of globotriaosylceramide (Gb3).
T2 96-266 Sentence denotes Fabry disease is a heritable lipid disorder caused by the low activity of α-galactosidase A and characterized by the systemic accumulation of globotriaosylceramide (Gb3).
T3 267-459 Sentence denotes Recent studies have reported a structural heterogeneity of Gb3 in Fabry disease, including Gb3 isoforms with different fatty acids and Gb3 analogs with modifications on the sphingosine moiety.
T3 267-459 Sentence denotes Recent studies have reported a structural heterogeneity of Gb3 in Fabry disease, including Gb3 isoforms with different fatty acids and Gb3 analogs with modifications on the sphingosine moiety.
T4 460-534 Sentence denotes However, Gb3 assays are often performed only on the selected Gb3 isoforms.
T4 460-534 Sentence denotes However, Gb3 assays are often performed only on the selected Gb3 isoforms.
T5 535-665 Sentence denotes To precisely determine the total Gb3 concentration, here we established two methods for determining both Gb3 isoforms and analogs.
T5 535-665 Sentence denotes To precisely determine the total Gb3 concentration, here we established two methods for determining both Gb3 isoforms and analogs.
T6 666-922 Sentence denotes One was the deacylation method, involving Gb3 treatment with sphingolipid ceramide N-deacylase, followed by an assay of the deacylated products, globotriaosylsphingosine (lyso-Gb3) and its analogs, by ultra-performance LC coupled to tandem MS (UPLC-MS/MS).
T6 666-922 Sentence denotes One was the deacylation method, involving Gb3 treatment with sphingolipid ceramide N-deacylase, followed by an assay of the deacylated products, globotriaosylsphingosine (lyso-Gb3) and its analogs, by ultra-performance LC coupled to tandem MS (UPLC-MS/MS).
T7 923-1047 Sentence denotes The other method was a direct assay established in the present study for 37 Gb3 isoforms and analogs/isoforms by UPLC-MS/MS.
T7 923-1047 Sentence denotes The other method was a direct assay established in the present study for 37 Gb3 isoforms and analogs/isoforms by UPLC-MS/MS.
T8 1048-1269 Sentence denotes Gb3s from the organs of symptomatic animals of a Fabry disease mouse model were mainly Gb3 isoforms and two Gb3 analogs, such as Gb3(+18) containing the lyso-Gb3(+18) moiety and Gb3(-2) containing the lyso-Gb3(-2) moiety.
T8 1048-1269 Sentence denotes Gb3s from the organs of symptomatic animals of a Fabry disease mouse model were mainly Gb3 isoforms and two Gb3 analogs, such as Gb3(+18) containing the lyso-Gb3(+18) moiety and Gb3(-2) containing the lyso-Gb3(-2) moiety.
T9 1270-1370 Sentence denotes The total concentrations and Gb3 analog distributions determined by the two methods were comparable.
T9 1270-1370 Sentence denotes The total concentrations and Gb3 analog distributions determined by the two methods were comparable.
T10 1371-1516 Sentence denotes Gb3(+18) levels were high in the kidneys (24% of total Gb3) and the liver (13%), and we observed Gb3(-2) in the heart (10%) and the kidneys (5%).
T10 1371-1516 Sentence denotes Gb3(+18) levels were high in the kidneys (24% of total Gb3) and the liver (13%), and we observed Gb3(-2) in the heart (10%) and the kidneys (5%).
T11 1517-1671 Sentence denotes These results indicate organ-specific expression of Gb3 analogs, insights that may lead to a deeper understanding of the pathophysiology of Fabry disease.
T11 1517-1671 Sentence denotes These results indicate organ-specific expression of Gb3 analogs, insights that may lead to a deeper understanding of the pathophysiology of Fabry disease.