| Id |
Subject |
Object |
Predicate |
Lexical cue |
| TextSentencer_T1 |
0-141 |
Sentence |
denotes |
Synthesis and characterization of lyso-GM3 (II3Neu5Ac Lactosyl sphingosine), de-N-acetyl-GM3 (II3NeuNH2 lactosyl Cer), and related compounds. |
| T1 |
0-141 |
Sentence |
denotes |
Synthesis and characterization of lyso-GM3 (II3Neu5Ac Lactosyl sphingosine), de-N-acetyl-GM3 (II3NeuNH2 lactosyl Cer), and related compounds. |
| TextSentencer_T2 |
142-264 |
Sentence |
denotes |
Various GM3 derivatives which are present in A431 cells have different effects on the activity of the EGF receptor kinase. |
| T2 |
142-264 |
Sentence |
denotes |
Various GM3 derivatives which are present in A431 cells have different effects on the activity of the EGF receptor kinase. |
| TextSentencer_T3 |
265-515 |
Sentence |
denotes |
In order to systematically study these effects, the following GM3 derivatives have been synthesized: de-N-acetyl-GM3 (D1), de-N-acetyl-lyso-GM3 (D2), lyso-GM3 (D3), de-N-acetyl-GM3 with N-acetylsphingosine (D4), and GM3 with N-acetylsphingosine (D3). |
| T3 |
265-515 |
Sentence |
denotes |
In order to systematically study these effects, the following GM3 derivatives have been synthesized: de-N-acetyl-GM3 (D1), de-N-acetyl-lyso-GM3 (D2), lyso-GM3 (D3), de-N-acetyl-GM3 with N-acetylsphingosine (D4), and GM3 with N-acetylsphingosine (D3). |
| TextSentencer_T4 |
516-685 |
Sentence |
denotes |
A crucial step for the preparation of D1 is the use of mild alkaline conditions of hydrolysis under which the N-acetyl group of sialic acid is preferentially hydrolyzed. |
| T4 |
516-685 |
Sentence |
denotes |
A crucial step for the preparation of D1 is the use of mild alkaline conditions of hydrolysis under which the N-acetyl group of sialic acid is preferentially hydrolyzed. |
| TextSentencer_T5 |
686-1104 |
Sentence |
denotes |
For the preparation of D3, conditions which allowed preferential N-acetylation of the amino group of the neuraminic acid moiety were devised, i.e., D2 was incorporated in a dipalmitoyl-phosphatidylcholine (dpPC) liposome in which the sphingosine moiety was protected and the amino group of neuraminic acid was N-acetylated with acetate and a water-soluble catalyst, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide (DEC). |
| T5 |
686-1104 |
Sentence |
denotes |
For the preparation of D3, conditions which allowed preferential N-acetylation of the amino group of the neuraminic acid moiety were devised, i.e., D2 was incorporated in a dipalmitoyl-phosphatidylcholine (dpPC) liposome in which the sphingosine moiety was protected and the amino group of neuraminic acid was N-acetylated with acetate and a water-soluble catalyst, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide (DEC). |
| TextSentencer_T6 |
1105-1310 |
Sentence |
denotes |
When an aqueous micellar solution of D2 was treated with acetic anhydride and sodium hydrogencarbonate, N-acetylation occurred at the amino groups of both neuraminosyl and sphingosyl residues, yielding D5. |
| T6 |
1105-1310 |
Sentence |
denotes |
When an aqueous micellar solution of D2 was treated with acetic anhydride and sodium hydrogencarbonate, N-acetylation occurred at the amino groups of both neuraminosyl and sphingosyl residues, yielding D5. |
| TextSentencer_T7 |
1311-1409 |
Sentence |
denotes |
The structures of these derivatives were verified by 1H-n.m.r. spectroscopy and mass spectrometry. |
| T7 |
1311-1409 |
Sentence |
denotes |
The structures of these derivatives were verified by 1H-n.m.r. spectroscopy and mass spectrometry. |
