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PubMed:31690624 JSONTXT 27 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-117 Sentence denotes Tango1 coordinates the formation of endoplasmic reticulum/Golgi docking sites to mediate secretory granule formation.
T2 118-204 Sentence denotes Regulated secretion is a conserved process occurring across diverse cells and tissues.
T3 205-425 Sentence denotes Current models suggest that the conserved cargo receptor Tango1 mediates the packaging of collagen into large coat protein complex II (COPII) vesicles that move from the endoplasmic reticulum (ER) to the Golgi apparatus.
T4 426-548 Sentence denotes However, how Tango1 regulates the formation of COPII carriers and influences the secretion of other cargo remains unknown.
T5 549-790 Sentence denotes Here, through high-resolution imaging of Tango1, COPII, Golgi, and secretory cargo (mucins) in Drosophila larval salivary glands, we found that Tango1 forms ring-like structures that mediate the formation of COPII rings rather than vesicles.
T6 791-848 Sentence denotes These COPII rings act as docking sites for the cis-Golgi.
T7 849-1086 Sentence denotes Moreover, we observed nascent secretory mucins emerging from the Golgi side of these Tango1-COPII-Golgi complexes, suggesting that these structures represent functional docking sites/fusion points between the ER exit sites and the Golgi.
T8 1087-1245 Sentence denotes Loss of Tango1 disrupted the formation of COPII rings, the association of COPII with the cis-Golgi, mucin O-glycosylation, and secretory granule biosynthesis.
T9 1246-1357 Sentence denotes Additionally, we identified a Tango1 self-association domain that is essential for formation of this structure.
T10 1358-1530 Sentence denotes Our results provide evidence that Tango1 organizes an interaction site where secretory cargo is efficiently transferred from the ER to Golgi and then to secretory vesicles.
T11 1531-1680 Sentence denotes These findings may explain how the loss of Tango1 can influence Golgi/ER morphology and affect the secretion of diverse proteins across many tissues.