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PubMed:30994353 JSONTXT 40 Projects

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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-80 Sentence denotes Quantitative Interrogation of the Human Kinome Perturbed by Two BRAF Inhibitors.
T1 0-80 Sentence denotes Quantitative Interrogation of the Human Kinome Perturbed by Two BRAF Inhibitors.
TextSentencer_T2 81-279 Sentence denotes Oncogenic BRAF mutations contribute to the development of a number of cancers, and small-molecule BRAF inhibitors have been approved by the Food and Drug Administration (FDA) for anticancer therapy.
T2 81-279 Sentence denotes Oncogenic BRAF mutations contribute to the development of a number of cancers, and small-molecule BRAF inhibitors have been approved by the Food and Drug Administration (FDA) for anticancer therapy.
TextSentencer_T3 280-578 Sentence denotes In this study, we employed two targeted quantitative proteomics approaches for monitoring separately the alterations in protein expression and ATP binding affinities of kinases in cultured human melanoma cells elicited by two FDA-approved small-molecule BRAF inhibitors, dabrafenib and vemurafenib.
T3 280-578 Sentence denotes In this study, we employed two targeted quantitative proteomics approaches for monitoring separately the alterations in protein expression and ATP binding affinities of kinases in cultured human melanoma cells elicited by two FDA-approved small-molecule BRAF inhibitors, dabrafenib and vemurafenib.
TextSentencer_T4 579-696 Sentence denotes Our results showed that treatment with the two inhibitors led to markedly different reprograming of the human kinome.
T4 579-696 Sentence denotes Our results showed that treatment with the two inhibitors led to markedly different reprograming of the human kinome.
TextSentencer_T5 697-842 Sentence denotes Furthermore, we confirmed that vemurafenib could compromise the ATP binding capacity of MAP2K5 in vitro and inhibit its kinase activity in cells.
T5 697-842 Sentence denotes Furthermore, we confirmed that vemurafenib could compromise the ATP binding capacity of MAP2K5 in vitro and inhibit its kinase activity in cells.
TextSentencer_T6 843-1121 Sentence denotes Together, our targeted quantitative proteomic methods revealed profound changes in expression levels of kinase proteins in cultured melanoma cells upon treatment with clinically used BRAF inhibitors and led to the discovery of novel putative target kinases for these inhibitors.
T6 843-1121 Sentence denotes Together, our targeted quantitative proteomic methods revealed profound changes in expression levels of kinase proteins in cultured melanoma cells upon treatment with clinically used BRAF inhibitors and led to the discovery of novel putative target kinases for these inhibitors.