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PubMed:30913288 JSONTXT 27 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-113 Sentence denotes Structural basis for specific recognition of core fucosylation in N-glycans by Pholiota squarrosa lectin (PhoSL).
T1 0-113 Sentence denotes Structural basis for specific recognition of core fucosylation in N-glycans by Pholiota squarrosa lectin (PhoSL).
TextSentencer_T2 114-296 Sentence denotes Fucosylation of the N-glycan core via the α1-6 linkage (core fucosylation) is detected in specific types of cancers and related diseases, and thereby serves for a relevant biomarker.
T2 114-296 Sentence denotes Fucosylation of the N-glycan core via the α1-6 linkage (core fucosylation) is detected in specific types of cancers and related diseases, and thereby serves for a relevant biomarker.
TextSentencer_T3 297-546 Sentence denotes The lectin from a mushroom Pholiota squarrosa (PhoSL) shows a clear specificity to core fucosylation, without recognizing those with other types of fucosylation, such as the H type via the α1-2 linkage or the Lewis type via the α1-3 or α1-4 linkage.
T3 297-546 Sentence denotes The lectin from a mushroom Pholiota squarrosa (PhoSL) shows a clear specificity to core fucosylation, without recognizing those with other types of fucosylation, such as the H type via the α1-2 linkage or the Lewis type via the α1-3 or α1-4 linkage.
TextSentencer_T4 547-680 Sentence denotes Here we determined the crystal structure of the PhoSL trimer in complex with a disaccharide fucose(α1-6)N-acetylglucosamine (GlcNAc).
T4 547-680 Sentence denotes Here we determined the crystal structure of the PhoSL trimer in complex with a disaccharide fucose(α1-6)N-acetylglucosamine (GlcNAc).
TextSentencer_T5 681-813 Sentence denotes In the three sugar-binding pockets of PhoSL, extensive hydrophobic and hydrogen-bonding contacts were formed with the fucose moiety.
T5 681-813 Sentence denotes In the three sugar-binding pockets of PhoSL, extensive hydrophobic and hydrogen-bonding contacts were formed with the fucose moiety.
TextSentencer_T6 814-905 Sentence denotes In contrast, the GlcNAc moiety showed only a few hydrophobic and hydrogen-bonding contacts.
T6 814-905 Sentence denotes In contrast, the GlcNAc moiety showed only a few hydrophobic and hydrogen-bonding contacts.
TextSentencer_T7 906-1094 Sentence denotes To elucidate the mechanism for the specificity, we performed molecular dynamics simulations on this disaccharide and a trisaccharide fucose(α1-6)[GlcNAc(β1-4)]GlcNAc in complex with PhoSL.
T7 906-1094 Sentence denotes To elucidate the mechanism for the specificity, we performed molecular dynamics simulations on this disaccharide and a trisaccharide fucose(α1-6)[GlcNAc(β1-4)]GlcNAc in complex with PhoSL.
TextSentencer_T8 1095-1329 Sentence denotes It was observed that the GlcNAc corresponding to the outer one of the N-glycan core entered the sugar-binding pocket with the N-acetyl group placed stably at the bottom, forming extensive hydrophobic and hydrogen-bonding interactions.
T8 1095-1329 Sentence denotes It was observed that the GlcNAc corresponding to the outer one of the N-glycan core entered the sugar-binding pocket with the N-acetyl group placed stably at the bottom, forming extensive hydrophobic and hydrogen-bonding interactions.
TextSentencer_T9 1330-1420 Sentence denotes In addition, these glycans adopted unstressed favorable conformations when bound to PhoSL.
T9 1330-1420 Sentence denotes In addition, these glycans adopted unstressed favorable conformations when bound to PhoSL.
TextSentencer_T10 1421-1617 Sentence denotes In contrast, H- and Lewis-types of fucosylated trisaccharides adopting favorable conformations caused inevitable steric hindrance with the steep edge of the binding pocket, when docked with PhoSL.
T10 1421-1617 Sentence denotes In contrast, H- and Lewis-types of fucosylated trisaccharides adopting favorable conformations caused inevitable steric hindrance with the steep edge of the binding pocket, when docked with PhoSL.
TextSentencer_T11 1618-1752 Sentence denotes Therefore, the specificity to core fucosylation of PhoSL was achieved by a combination of these preferential and exclusive mechanisms.
T11 1618-1752 Sentence denotes Therefore, the specificity to core fucosylation of PhoSL was achieved by a combination of these preferential and exclusive mechanisms.