| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-106 |
Sentence |
denotes |
Aminoacyl-tRNA synthetases and tRNAs in human disease: an introduction to the JBC Reviews thematic series. |
| T2 |
107-235 |
Sentence |
denotes |
Aminoacyl-tRNA synthetases (ARSs) catalyze the attachment of specific amino acids to cognate tRNAs for use in protein synthesis. |
| T3 |
236-305 |
Sentence |
denotes |
This historical function of ARSs and tRNAs is fairly well understood. |
| T4 |
306-417 |
Sentence |
denotes |
However, ARSs and tRNAs also perform noncanonical functions that are continuing to be unveiled at a rapid pace. |
| T5 |
418-700 |
Sentence |
denotes |
The expanded functions of these essential molecules of life range from roles in retroviral replication to stimulation of mammalian target of rapamycin (mTOR) activity; DNA repair, splicing, and transcriptional and translational regulation; and other aspects of cellular homeostasis. |
| T6 |
701-915 |
Sentence |
denotes |
Furthermore, mutations in tRNAs and synthetases are known to drive human maladies, such as the neurodegenerative disorder Charcot-Marie-Tooth disease along with other central nervous system dysfunctions and cancer. |
| T7 |
916-1085 |
Sentence |
denotes |
This series of reviews focuses on the diseases that result from natural variations in human cytoplasmic tRNAs, as well as from mutations in mitochondrial tRNAs and ARSs. |
| T8 |
1086-1251 |
Sentence |
denotes |
Ultimately, the exciting work in this rapidly emerging area may lead to new therapies for microbial and parasitic infections, cancer, and neurodegenerative diseases. |
