| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-121 |
Sentence |
denotes |
O-GlcNAcylation reduces proximal tubule protein reabsorption and promotes proteinuria in spontaneously hypertensive rats. |
| T2 |
122-211 |
Sentence |
denotes |
Hypertensive individuals are at greater risk for developing chronic kidney disease (CKD). |
| T3 |
212-300 |
Sentence |
denotes |
Reducing proteinuria has been suggested as a possible therapeutic approach to treat CKD. |
| T4 |
301-422 |
Sentence |
denotes |
However, the mechanisms underlying the development of proteinuria in hypertensive conditions are incompletely understood. |
| T5 |
423-537 |
Sentence |
denotes |
Cardiac and vascular dysfunction is associated with changes in the O-GlcNAcylation pathway in hypertensive models. |
| T6 |
538-677 |
Sentence |
denotes |
We hypothesized that O-GlcNAcylation is also involved in renal damage, especially development of proteinuria, associated with hypertension. |
| T7 |
678-921 |
Sentence |
denotes |
Using the spontaneously hypertensive rat (SHR) model, we observed higher renal cortex O-GlcNAcylation, glutamine-fructose aminotransferase (GFAT), and O-GlcNAc transferase (OGT) protein expression, which positively correlated with proteinuria. |
| T8 |
922-1003 |
Sentence |
denotes |
Interestingly, this was observed in hypertensive, but not pre-hypertensive, rats. |
| T9 |
1004-1115 |
Sentence |
denotes |
Pharmacological inhibition of GFAT decreased renal cortex O-GlcNAcylation, proteinuria, and albuminuria in SHR. |
| T10 |
1116-1468 |
Sentence |
denotes |
Using a proximal tubule cell line, we observed that increased O-GlcNAcylation reduced megalin surface expression and albumin endocytosis in vitro, and the effects were correlated in vivo Moreover, megalin is O-GlcNAcylated both in vitro and in vivo In conclusion, our results demonstrate a new mechanism involved in hypertension-associated proteinuria. |
