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PubMed:29175660 JSONTXT 43 Projects

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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-103 Sentence denotes Chemo-enzymatic synthesis of the glucagon containing N-linked oligosaccharide and its characterization.
T1 0-103 Sentence denotes Chemo-enzymatic synthesis of the glucagon containing N-linked oligosaccharide and its characterization.
TextSentencer_T2 104-261 Sentence denotes The chemo-enzymatic synthesis of an artificially N-glycosylated derivative of glucagon, a peptide hormone that regulates the blood sugar level, is described.
T2 104-261 Sentence denotes The chemo-enzymatic synthesis of an artificially N-glycosylated derivative of glucagon, a peptide hormone that regulates the blood sugar level, is described.
TextSentencer_T3 262-591 Sentence denotes We synthesized the glycosylated glucagon by chemical synthesis of an N-acetylglucosaminyl peptide and enzymatic transfer of an oligosaccharide using the transglycosylation activity of the glycosynthase-like mutant of Mucor hiemalis endo-β-N-acetylglucosaminidase (Endo-M) and sialo-oligosaccharide oxazoline as a donor substrate.
T3 262-591 Sentence denotes We synthesized the glycosylated glucagon by chemical synthesis of an N-acetylglucosaminyl peptide and enzymatic transfer of an oligosaccharide using the transglycosylation activity of the glycosynthase-like mutant of Mucor hiemalis endo-β-N-acetylglucosaminidase (Endo-M) and sialo-oligosaccharide oxazoline as a donor substrate.
TextSentencer_T4 592-781 Sentence denotes The sialo-oligosaccharide-attached glucagon synthesized showed high resistance against protease degradation and stimulated the release of glucose from mouse hepatocytes when added to cells.
T4 592-781 Sentence denotes The sialo-oligosaccharide-attached glucagon synthesized showed high resistance against protease degradation and stimulated the release of glucose from mouse hepatocytes when added to cells.
TextSentencer_T5 782-930 Sentence denotes The synthetic glucagon showed slightly higher activity than native glucagon and has potential as a therapeutic agent for treating diabetic patients.
T5 782-930 Sentence denotes The synthetic glucagon showed slightly higher activity than native glucagon and has potential as a therapeutic agent for treating diabetic patients.