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PubMed:28973141 JSONTXT 27 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-74 Sentence denotes Core fucose is critical for CD14-dependent Toll-like receptor 4 signaling.
T1 0-74 Sentence denotes Core fucose is critical for CD14-dependent Toll-like receptor 4 signaling.
TextSentencer_T2 75-227 Sentence denotes Core fucosylation, a posttranslational modification of N-glycans, modifies several growth factor receptors and impacts on their ligand binding affinity.
T2 75-227 Sentence denotes Core fucosylation, a posttranslational modification of N-glycans, modifies several growth factor receptors and impacts on their ligand binding affinity.
TextSentencer_T3 228-458 Sentence denotes Core-fucose-deficient mice generated by ablating the α1,6 fucosyltransferase enzyme, Fut8, exhibit severe pulmonary emphysema, partly due to impaired macrophage function, similar to aged Toll-like receptor 4 (Tlr4)-deficient mice.
T3 228-458 Sentence denotes Core-fucose-deficient mice generated by ablating the α1,6 fucosyltransferase enzyme, Fut8, exhibit severe pulmonary emphysema, partly due to impaired macrophage function, similar to aged Toll-like receptor 4 (Tlr4)-deficient mice.
TextSentencer_T4 459-552 Sentence denotes We therefore suspect that a lack of core fucose affects the TLR4-dependent signaling pathway.
T4 459-552 Sentence denotes We therefore suspect that a lack of core fucose affects the TLR4-dependent signaling pathway.
TextSentencer_T5 553-770 Sentence denotes Indeed, upon lipopolysaccharide stimulation, Fut8-deficient mouse embryonic fibroblasts (MEFs) produced similar levels of interleukin-6 but markedly reduced levels of interferon-β (IFN-β) compared with wild-type MEFs.
T5 553-770 Sentence denotes Indeed, upon lipopolysaccharide stimulation, Fut8-deficient mouse embryonic fibroblasts (MEFs) produced similar levels of interleukin-6 but markedly reduced levels of interferon-β (IFN-β) compared with wild-type MEFs.
TextSentencer_T6 771-885 Sentence denotes Lectin blot analysis of the TLR4 signaling complex revealed that core fucosylation was specifically found on CD14.
T6 771-885 Sentence denotes Lectin blot analysis of the TLR4 signaling complex revealed that core fucosylation was specifically found on CD14.
TextSentencer_T7 886-1124 Sentence denotes Even though similar levels of TLR4/myeloid differentiation factor 2 (MD2) activation and dimerization were observed in Fut8-deficient cells after lipopolysaccharide stimulation, internalization of TLR4 and CD14 was significantly impaired.
T7 886-1124 Sentence denotes Even though similar levels of TLR4/myeloid differentiation factor 2 (MD2) activation and dimerization were observed in Fut8-deficient cells after lipopolysaccharide stimulation, internalization of TLR4 and CD14 was significantly impaired.
TextSentencer_T8 1125-1283 Sentence denotes Given that internalized TLR4/MD2 induces IFN-β production, impaired IFN-β production in Fut8-deficient cells is ascribed to impaired TLR4/MD2 internalization.
T8 1125-1283 Sentence denotes Given that internalized TLR4/MD2 induces IFN-β production, impaired IFN-β production in Fut8-deficient cells is ascribed to impaired TLR4/MD2 internalization.
TextSentencer_T9 1284-1374 Sentence denotes These data show for the first time that glycosylation critically regulates TLR4 signaling.
T9 1284-1374 Sentence denotes These data show for the first time that glycosylation critically regulates TLR4 signaling.