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PubMed:28624519 JSONTXT 29 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-184 Sentence denotes iTRAQ-based quantitative proteomics analysis of molecular mechanisms associated with Bombyx mori (Lepidoptera) larval midgut response to BmNPV in susceptible and near-isogenic strains.
T1 0-184 Sentence denotes iTRAQ-based quantitative proteomics analysis of molecular mechanisms associated with Bombyx mori (Lepidoptera) larval midgut response to BmNPV in susceptible and near-isogenic strains.
T2 185-303 Sentence denotes Bombyx mori nucleopolyhedrovirus (BmNPV) has been identified as a major pathogen responsible for severe economic loss.
T2 185-303 Sentence denotes Bombyx mori nucleopolyhedrovirus (BmNPV) has been identified as a major pathogen responsible for severe economic loss.
T3 304-413 Sentence denotes Most silkworm strains are susceptible to BmNPV, with only a few highly resistant strains thus far identified.
T3 304-413 Sentence denotes Most silkworm strains are susceptible to BmNPV, with only a few highly resistant strains thus far identified.
T4 414-697 Sentence denotes Here we investigated the molecular basis of silkworm resistance to BmNPV using susceptible (the recurrent parent P50) and resistant (near-isogenic line BC9) strains and a combination of iTRAQ-based quantitative proteomics, reverse-transcription quantitative PCR and Western blotting.
T4 414-697 Sentence denotes Here we investigated the molecular basis of silkworm resistance to BmNPV using susceptible (the recurrent parent P50) and resistant (near-isogenic line BC9) strains and a combination of iTRAQ-based quantitative proteomics, reverse-transcription quantitative PCR and Western blotting.
T5 698-836 Sentence denotes By comparing the proteomes of infected and non-infected P50 and BC9 silkworms, we identified 793 differentially expressed proteins (DEPs).
T5 698-836 Sentence denotes By comparing the proteomes of infected and non-infected P50 and BC9 silkworms, we identified 793 differentially expressed proteins (DEPs).
T6 837-1038 Sentence denotes By gene ontology and KEGG enrichment analyses, we found that these DEPs are preferentially involved in metabolism, catalytic activity, amino sugar and nucleotide sugar metabolism and carbon metabolism.
T6 837-1038 Sentence denotes By gene ontology and KEGG enrichment analyses, we found that these DEPs are preferentially involved in metabolism, catalytic activity, amino sugar and nucleotide sugar metabolism and carbon metabolism.
T7 1039-1207 Sentence denotes 114 (14.38%) DEPs were associated with the cytoskeleton, immune response, apoptosis, ubiquitination, translation, ion transport, endocytosis and endopeptidase activity.
T7 1039-1207 Sentence denotes 114 (14.38%) DEPs were associated with the cytoskeleton, immune response, apoptosis, ubiquitination, translation, ion transport, endocytosis and endopeptidase activity.
T8 1208-1380 Sentence denotes After removing the genetic background and individual immune stress response proteins, we identified 84 DEPs were found that are potentially involved in resistance to BmNPV.
T8 1208-1380 Sentence denotes After removing the genetic background and individual immune stress response proteins, we identified 84 DEPs were found that are potentially involved in resistance to BmNPV.
T9 1381-1499 Sentence denotes Further studies showed that a serine protease was down-regulated in P50 and up-regulated in BC9 after BmNPV infection.
T9 1381-1499 Sentence denotes Further studies showed that a serine protease was down-regulated in P50 and up-regulated in BC9 after BmNPV infection.
T10 1500-1606 Sentence denotes Taken together, these results provide insights into the molecular mechanism of silkworm response to BmNPV.
T10 1500-1606 Sentence denotes Taken together, these results provide insights into the molecular mechanism of silkworm response to BmNPV.
T11 1607-1631 Sentence denotes BIOLOGICAL SIGNIFICANCE:
T11 1607-1631 Sentence denotes BIOLOGICAL SIGNIFICANCE:
T12 1632-1744 Sentence denotes Bombyx mori nucleopolyhedrovirus (BmNPV) is highly pathogenic, causing serious losses in sericulture every year.
T12 1632-1744 Sentence denotes Bombyx mori nucleopolyhedrovirus (BmNPV) is highly pathogenic, causing serious losses in sericulture every year.
T13 1745-1830 Sentence denotes However, the molecular mechanisms of BmNPV infection and host defence remain unclear.
T13 1745-1830 Sentence denotes However, the molecular mechanisms of BmNPV infection and host defence remain unclear.
T14 1831-2176 Sentence denotes Here we combined quantitative proteomic, bioinformatics, RT-qPCR and Western blotting analyses and found that BmNPV invasion causes complex protein alterations in the larval midgut, and that these changes are related to cytoskeleton, immune response, apoptosis, ubiquitination, translation, ion transport, endocytosis and endopeptidase activity.
T14 1831-2176 Sentence denotes Here we combined quantitative proteomic, bioinformatics, RT-qPCR and Western blotting analyses and found that BmNPV invasion causes complex protein alterations in the larval midgut, and that these changes are related to cytoskeleton, immune response, apoptosis, ubiquitination, translation, ion transport, endocytosis and endopeptidase activity.
T15 2177-2269 Sentence denotes Five important differentially expression proteins were validation by independent approaches.
T15 2177-2269 Sentence denotes Five important differentially expression proteins were validation by independent approaches.
T16 2270-2410 Sentence denotes These finding will help address the molecular mechanisms of silkworm resistance to BmNPV and provide a molecular target for resisting BmNPV.
T16 2270-2410 Sentence denotes These finding will help address the molecular mechanisms of silkworm resistance to BmNPV and provide a molecular target for resisting BmNPV.