Id |
Subject |
Object |
Predicate |
Lexical cue |
TextSentencer_T1 |
0-129 |
Sentence |
denotes |
Structural and functional characterization of a novel immunomodulatory glycoprotein isolated from ajowan (Trachyspermum ammi L.). |
T1 |
0-129 |
Sentence |
denotes |
Structural and functional characterization of a novel immunomodulatory glycoprotein isolated from ajowan (Trachyspermum ammi L.). |
TextSentencer_T2 |
130-249 |
Sentence |
denotes |
Ajowan (Trachyspermum ammi L.) spice has been used in food preparations and also as a traditional medicine in Ayurveda. |
T2 |
130-249 |
Sentence |
denotes |
Ajowan (Trachyspermum ammi L.) spice has been used in food preparations and also as a traditional medicine in Ayurveda. |
TextSentencer_T3 |
250-372 |
Sentence |
denotes |
Although a number of pharmacological activities have been attributed to ajowan, its role in immunomodulation is not known. |
T3 |
250-372 |
Sentence |
denotes |
Although a number of pharmacological activities have been attributed to ajowan, its role in immunomodulation is not known. |
TextSentencer_T4 |
373-474 |
Sentence |
denotes |
The main objective of the present study is to examine the macromolecular immunomodulatory components. |
T4 |
373-474 |
Sentence |
denotes |
The main objective of the present study is to examine the macromolecular immunomodulatory components. |
TextSentencer_T5 |
475-611 |
Sentence |
denotes |
Macrophage activation was studied by nitric oxide (NO) release, phagocytosis and secretion of pro-inflammatory cytokines as the markers. |
T5 |
475-611 |
Sentence |
denotes |
Macrophage activation was studied by nitric oxide (NO) release, phagocytosis and secretion of pro-inflammatory cytokines as the markers. |
TextSentencer_T6 |
612-756 |
Sentence |
denotes |
Ethanol precipitate (fractional) of ajowan aqueous extract was subjected to conventional chromatography (Q Sepharose followed by Bio-Gel P-100). |
T6 |
612-756 |
Sentence |
denotes |
Ethanol precipitate (fractional) of ajowan aqueous extract was subjected to conventional chromatography (Q Sepharose followed by Bio-Gel P-100). |
TextSentencer_T7 |
757-872 |
Sentence |
denotes |
One of the proteins (30.7 kDa; ajowan glycoprotein or Agp) showed effective mitogenic activity towards splenocytes. |
T7 |
757-872 |
Sentence |
denotes |
One of the proteins (30.7 kDa; ajowan glycoprotein or Agp) showed effective mitogenic activity towards splenocytes. |
TextSentencer_T8 |
873-969 |
Sentence |
denotes |
Agp is a O-linked glycoprotein with the glycans contributing to one-third of the molecular mass. |
T8 |
873-969 |
Sentence |
denotes |
Agp is a O-linked glycoprotein with the glycans contributing to one-third of the molecular mass. |
TextSentencer_T9 |
970-1160 |
Sentence |
denotes |
It has a high content of glutamic acid, serine, aspartic acid and proline whereas galactose (45.7%), arabinose (34.5%), glucose (7%), mannose (5%) and xylose (4%) are the constituent sugars. |
T9 |
970-1160 |
Sentence |
denotes |
It has a high content of glutamic acid, serine, aspartic acid and proline whereas galactose (45.7%), arabinose (34.5%), glucose (7%), mannose (5%) and xylose (4%) are the constituent sugars. |
TextSentencer_T10 |
1161-1252 |
Sentence |
denotes |
Secondary structure analysis indicated that Agp contains 79% α-helices and 21% random coil. |
T10 |
1161-1252 |
Sentence |
denotes |
Secondary structure analysis indicated that Agp contains 79% α-helices and 21% random coil. |
TextSentencer_T11 |
1253-1370 |
Sentence |
denotes |
Internal sequencing of the tryptic peptides did not show homology with the existing proteins in the database (BLAST). |
T11 |
1253-1370 |
Sentence |
denotes |
Internal sequencing of the tryptic peptides did not show homology with the existing proteins in the database (BLAST). |
TextSentencer_T12 |
1371-1525 |
Sentence |
denotes |
Agp at 1 μg/mL induced proliferation of B-cell enriched murine splenocytes and activated macrophages in releasing NO and promoted phagocytosis (p < 0.01). |
T12 |
1371-1525 |
Sentence |
denotes |
Agp at 1 μg/mL induced proliferation of B-cell enriched murine splenocytes and activated macrophages in releasing NO and promoted phagocytosis (p < 0.01). |
TextSentencer_T13 |
1526-1629 |
Sentence |
denotes |
RAW 264.7 cells produced pro-inflammatory cytokines (IL-12, TNF-α and IFN-γ) at 1 μg/mL Agp (p < 0.01). |
T13 |
1526-1629 |
Sentence |
denotes |
RAW 264.7 cells produced pro-inflammatory cytokines (IL-12, TNF-α and IFN-γ) at 1 μg/mL Agp (p < 0.01). |
TextSentencer_T14 |
1630-1781 |
Sentence |
denotes |
Deproteinized Agp (dpAgp) failed to elicit activation of murine immune cells, whereas deglycosylated Agp (20 kDa; dgAgp) showed compromised efficiency. |
T14 |
1630-1781 |
Sentence |
denotes |
Deproteinized Agp (dpAgp) failed to elicit activation of murine immune cells, whereas deglycosylated Agp (20 kDa; dgAgp) showed compromised efficiency. |
TextSentencer_T15 |
1782-1850 |
Sentence |
denotes |
This is the first report of an immunomodulatory protein from ajowan. |
T15 |
1782-1850 |
Sentence |
denotes |
This is the first report of an immunomodulatory protein from ajowan. |