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Id Subject Object Predicate Lexical cue
T1 0-53 Sentence denotes Inositol polyphosphate 1-phosphatase from calf brain.
T1 0-53 Sentence denotes Inositol polyphosphate 1-phosphatase from calf brain.
T2 54-105 Sentence denotes Purification and inhibition by Li+, Ca2+, and Mn2+.
T2 54-105 Sentence denotes Purification and inhibition by Li+, Ca2+, and Mn2+.
T3 106-408 Sentence denotes We recently identified an enzyme which we have designated inositol polyphosphate 1-phosphatase that hydrolyzes both inositol 1,3,4-trisphosphate (Ins-1,3,4-P3) and inositol 1,4-bisphosphate (Ins-1,4-P2), yielding inositol 3,4-bisphosphate and inositol 4-phosphate, respectively, as products (Inhorn, R.
T3 106-408 Sentence denotes We recently identified an enzyme which we have designated inositol polyphosphate 1-phosphatase that hydrolyzes both inositol 1,3,4-trisphosphate (Ins-1,3,4-P3) and inositol 1,4-bisphosphate (Ins-1,4-P2), yielding inositol 3,4-bisphosphate and inositol 4-phosphate, respectively, as products (Inhorn, R.
T4 409-457 Sentence denotes C., Bansal, V.S., and Majerus, P.W. (1987) Proc.
T4 409-457 Sentence denotes C., Bansal, V.S., and Majerus, P.W. (1987) Proc.
T5 458-463 Sentence denotes Natl.
T5 458-463 Sentence denotes Natl.
T6 464-469 Sentence denotes Acad.
T6 464-469 Sentence denotes Acad.
T7 470-474 Sentence denotes Sci.
T7 470-474 Sentence denotes Sci.
T8 475-481 Sentence denotes U.S.A.
T8 475-481 Sentence denotes U.S.A.
T9 482-497 Sentence denotes 84, 2170-2174).
T9 482-497 Sentence denotes 84, 2170-2174).
T10 498-598 Sentence denotes We have now purified the inositol polyphosphate 1-phosphatase 3600-fold from calf brain supernatant.
T10 498-598 Sentence denotes We have now purified the inositol polyphosphate 1-phosphatase 3600-fold from calf brain supernatant.
T11 599-763 Sentence denotes The purified enzyme has an apparent molecular mass of 44,000 daltons as determined by gel filtration and is free of other inositol phosphate phosphatase activities.
T11 599-763 Sentence denotes The purified enzyme has an apparent molecular mass of 44,000 daltons as determined by gel filtration and is free of other inositol phosphate phosphatase activities.
T12 764-924 Sentence denotes The enzyme hydrolyzes Ins-1,4-P2 with an apparent Km of approximately 4-5 microM, while it degrades Ins-1,3,4-P3 with an apparent Km of approximately 20 microM.
T12 764-924 Sentence denotes The enzyme hydrolyzes Ins-1,4-P2 with an apparent Km of approximately 4-5 microM, while it degrades Ins-1,3,4-P3 with an apparent Km of approximately 20 microM.
T13 925-1007 Sentence denotes The enzyme hydrolyzes these substrates at approximately the same maximal velocity.
T13 925-1007 Sentence denotes The enzyme hydrolyzes these substrates at approximately the same maximal velocity.
T14 1008-1144 Sentence denotes Inositol polyphosphate 1-phosphatase shows a sigmoidal dependence upon magnesium ion, with 0.3 mM Mg2+ causing half-maximal stimulation.
T14 1008-1144 Sentence denotes Inositol polyphosphate 1-phosphatase shows a sigmoidal dependence upon magnesium ion, with 0.3 mM Mg2+ causing half-maximal stimulation.
T15 1145-1261 Sentence denotes A Hill plot of the data is linear with a value of n = 1.9, suggesting that the enzyme binds magnesium cooperatively.
T15 1145-1261 Sentence denotes A Hill plot of the data is linear with a value of n = 1.9, suggesting that the enzyme binds magnesium cooperatively.
T16 1262-1355 Sentence denotes Calcium and manganese inhibit enzyme activity, with 50% inhibition at approximately 6 microM.
T16 1262-1355 Sentence denotes Calcium and manganese inhibit enzyme activity, with 50% inhibition at approximately 6 microM.
T17 1356-1443 Sentence denotes Lithium inhibits Ins-1,4-P2 hydrolysis uncompetitively with a Ki of approximately 6 mM.
T17 1356-1443 Sentence denotes Lithium inhibits Ins-1,4-P2 hydrolysis uncompetitively with a Ki of approximately 6 mM.
T18 1444-1646 Sentence denotes This mechanism of lithium inhibition is similar to that observed for the inositol monophosphate phosphatase (originally designated myo-inositol-1-phosphatase; Hallcher, L.M., and Sherman, W.R. (1980) J.
T18 1444-1646 Sentence denotes This mechanism of lithium inhibition is similar to that observed for the inositol monophosphate phosphatase (originally designated myo-inositol-1-phosphatase; Hallcher, L.M., and Sherman, W.R. (1980) J.
T19 1647-1652 Sentence denotes Biol.
T19 1647-1652 Sentence denotes Biol.
T20 1653-1658 Sentence denotes Chem.
T20 1653-1658 Sentence denotes Chem.
T21 1659-1724 Sentence denotes 255, 10896-10901), suggesting that these two enzymes are related.
T21 1659-1724 Sentence denotes 255, 10896-10901), suggesting that these two enzymes are related.
T22 1725-1804 Sentence denotes Lithium also inhibits Ins-1,3,4-P3 hydrolysis with an estimated Ki of 0.5-1 mM.
T22 1725-1804 Sentence denotes Lithium also inhibits Ins-1,3,4-P3 hydrolysis with an estimated Ki of 0.5-1 mM.