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PubMed:28184005 JSONTXT 22 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-153 Sentence denotes A C-terminal "Tail" Region in the Rous Sarcoma Virus Integrase Provides High Plasticity of Functional Integrase Oligomerization during Intasome Assembly.
T2 154-232 Sentence denotes The retrovirus integrase (IN) inserts the viral cDNA into the host DNA genome.
T3 233-481 Sentence denotes Atomic structures of five different retrovirus INs complexed with their respective viral DNA or branched viral/target DNA substrates have indicated these intasomes are composed of IN subunits ranging from tetramers, to octamers, or to hexadecamers.
T4 482-543 Sentence denotes IN precursors are monomers, dimers, or tetramers in solution.
T5 544-600 Sentence denotes But how intasome assembly is controlled remains unclear.
T6 601-682 Sentence denotes Therefore, we sought to unravel the functional mechanisms in different intasomes.
T7 683-889 Sentence denotes We produced kinetically stabilized Rous sarcoma virus (RSV) intasomes with human immunodeficiency virus type 1 strand transfer inhibitors that interact simultaneously with IN and viral DNA within intasomes.
T8 890-1048 Sentence denotes We examined the ability of RSV IN dimers to assemble two viral DNA molecules into intasomes containing IN tetramers in contrast to one possessing IN octamers.
T9 1049-1214 Sentence denotes We observed that the last 18 residues of the C terminus ("tail" region) of IN (residues 1-286) determined whether an IN tetramer or octamer assembled with viral DNA.
T10 1215-1407 Sentence denotes A series of truncations of the tail region indicated that these 18 residues are critical for the assembly of an intasome containing IN octamers but not for an intasome containing IN tetramers.
T11 1408-1549 Sentence denotes The C-terminally truncated IN (residues 1-269) produced an intasome that contained tetramers but failed to produce an intasome with octamers.
T12 1550-1599 Sentence denotes Both intasomes have similar catalytic activities.
T13 1600-1862 Sentence denotes The results suggest a high degree of plasticity for functional multimerization and reveal a critical role of the C-terminal tail region of IN in higher order oligomerization of intasomes, potentially informing future strategies to prevent retroviral integration.