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Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-159 Sentence denotes Schwannomin-interacting Protein 1 Isoform IQCJ-SCHIP1 Is a Multipartner Ankyrin- and Spectrin-binding Protein Involved in the Organization of Nodes of Ranvier.
T1 0-159 Sentence denotes Schwannomin-interacting Protein 1 Isoform IQCJ-SCHIP1 Is a Multipartner Ankyrin- and Spectrin-binding Protein Involved in the Organization of Nodes of Ranvier.
TextSentencer_T2 160-256 Sentence denotes The nodes of Ranvier are essential regions for action potential conduction in myelinated fibers.
T2 160-256 Sentence denotes The nodes of Ranvier are essential regions for action potential conduction in myelinated fibers.
TextSentencer_T3 257-390 Sentence denotes They are enriched in multimolecular complexes composed of voltage-gated Nav and Kv7 channels associated with cell adhesion molecules.
T3 257-390 Sentence denotes They are enriched in multimolecular complexes composed of voltage-gated Nav and Kv7 channels associated with cell adhesion molecules.
TextSentencer_T4 391-545 Sentence denotes Cytoskeletal proteins ankyrin-G (AnkG) and βIV-spectrin control the organization of these complexes and provide mechanical support to the plasma membrane.
T4 391-545 Sentence denotes Cytoskeletal proteins ankyrin-G (AnkG) and βIV-spectrin control the organization of these complexes and provide mechanical support to the plasma membrane.
TextSentencer_T5 546-637 Sentence denotes IQCJ-SCHIP1 is a cytoplasmic protein present in axon initial segments and nodes of Ranvier.
T5 546-637 Sentence denotes IQCJ-SCHIP1 is a cytoplasmic protein present in axon initial segments and nodes of Ranvier.
TextSentencer_T6 638-749 Sentence denotes It interacts with AnkG and is absent from nodes and axon initial segments of βIV-spectrin and AnkG mutant mice.
T6 638-749 Sentence denotes It interacts with AnkG and is absent from nodes and axon initial segments of βIV-spectrin and AnkG mutant mice.
TextSentencer_T7 750-915 Sentence denotes Here, we show that IQCJ-SCHIP1 also interacts with βIV-spectrin and Kv7.2/3 channels and self-associates, suggesting a scaffolding role in organizing nodal proteins.
T7 750-915 Sentence denotes Here, we show that IQCJ-SCHIP1 also interacts with βIV-spectrin and Kv7.2/3 channels and self-associates, suggesting a scaffolding role in organizing nodal proteins.
TextSentencer_T8 916-1025 Sentence denotes IQCJ-SCHIP1 binding requires a βIV-spectrin-specific domain and Kv7 channel 1-5-10 calmodulin-binding motifs.
T8 916-1025 Sentence denotes IQCJ-SCHIP1 binding requires a βIV-spectrin-specific domain and Kv7 channel 1-5-10 calmodulin-binding motifs.
TextSentencer_T9 1026-1151 Sentence denotes We then investigate the role of IQCJ-SCHIP1 in vivo by studying peripheral myelinated fibers in Schip1 knock-out mutant mice.
T9 1026-1151 Sentence denotes We then investigate the role of IQCJ-SCHIP1 in vivo by studying peripheral myelinated fibers in Schip1 knock-out mutant mice.
TextSentencer_T10 1152-1296 Sentence denotes The major nodal proteins are normally enriched at nodes in these mice, indicating that IQCJ-SCHIP1 is not required for their nodal accumulation.
T10 1152-1296 Sentence denotes The major nodal proteins are normally enriched at nodes in these mice, indicating that IQCJ-SCHIP1 is not required for their nodal accumulation.
TextSentencer_T11 1297-1595 Sentence denotes However, morphometric and ultrastructural analyses show an altered shape of nodes similar to that observed in βIV-spectrin mutant mice, revealing that IQCJ-SCHIP1 contributes to nodal membrane-associated cytoskeleton organization, likely through its interactions with the AnkG/βIV-spectrin network.
T11 1297-1595 Sentence denotes However, morphometric and ultrastructural analyses show an altered shape of nodes similar to that observed in βIV-spectrin mutant mice, revealing that IQCJ-SCHIP1 contributes to nodal membrane-associated cytoskeleton organization, likely through its interactions with the AnkG/βIV-spectrin network.
TextSentencer_T12 1596-1804 Sentence denotes Our work reveals that IQCJ-SCHIP1 interacts with several major nodal proteins, and we suggest that it contributes to a higher organizational level of the AnkG/βIV-spectrin network critical for node integrity.
T12 1596-1804 Sentence denotes Our work reveals that IQCJ-SCHIP1 interacts with several major nodal proteins, and we suggest that it contributes to a higher organizational level of the AnkG/βIV-spectrin network critical for node integrity.