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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-86 Sentence denotes Characterization of a proton-driven carrier for sialic acid in the lysosomal membrane.
T1 0-86 Sentence denotes Characterization of a proton-driven carrier for sialic acid in the lysosomal membrane.
TextSentencer_T2 87-161 Sentence denotes Evidence for a group-specific transport system for acidic monosaccharides.
T2 87-161 Sentence denotes Evidence for a group-specific transport system for acidic monosaccharides.
TextSentencer_T3 162-326 Sentence denotes Highly purified lysosomal membrane vesicles, obtained from rat liver lysosomes, were used to study characteristics of NeuAc transport across the lysosomal membrane.
T3 162-326 Sentence denotes Highly purified lysosomal membrane vesicles, obtained from rat liver lysosomes, were used to study characteristics of NeuAc transport across the lysosomal membrane.
TextSentencer_T4 327-421 Sentence denotes Uptake of [14C]NeuAc was found to be strongly influenced by a pH gradient across the membrane.
T4 327-421 Sentence denotes Uptake of [14C]NeuAc was found to be strongly influenced by a pH gradient across the membrane.
TextSentencer_T5 422-571 Sentence denotes When a proton gradient (pHin greater than pHout) was generated by impermeable buffers, NeuAc uptake above equilibrium level (overshoot) was observed.
T5 422-571 Sentence denotes When a proton gradient (pHin greater than pHout) was generated by impermeable buffers, NeuAc uptake above equilibrium level (overshoot) was observed.
TextSentencer_T6 572-686 Sentence denotes The influence of membrane diffusion potentials was ruled out by experiments where K+ and valinomycin were present.
T6 572-686 Sentence denotes The influence of membrane diffusion potentials was ruled out by experiments where K+ and valinomycin were present.
TextSentencer_T7 687-821 Sentence denotes The overshoot appeared to be specifically produced by protons, since gradients of other cations (Na+ and K+) did not give stimulation.
T7 687-821 Sentence denotes The overshoot appeared to be specifically produced by protons, since gradients of other cations (Na+ and K+) did not give stimulation.
TextSentencer_T8 822-949 Sentence denotes Proton-driven uptake was saturable (Kt = 0.24 mM) and mediated by a single system, as shown by linearity of the Scatchard plot.
T8 822-949 Sentence denotes Proton-driven uptake was saturable (Kt = 0.24 mM) and mediated by a single system, as shown by linearity of the Scatchard plot.
TextSentencer_T9 950-1193 Sentence denotes Stimulation of transport was also obtained by preincubation of vesicles with MgATP and the effect was blocked by 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid, but not by the protonophore carbonyl cyanide p-trifluoromethoxyphenyl hydrazone.
T9 950-1193 Sentence denotes Stimulation of transport was also obtained by preincubation of vesicles with MgATP and the effect was blocked by 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid, but not by the protonophore carbonyl cyanide p-trifluoromethoxyphenyl hydrazone.
TextSentencer_T10 1194-1291 Sentence denotes Monocarboxylic sugars like glycuronic acids were competitive inhibitors of sialic acid transport.
T10 1194-1291 Sentence denotes Monocarboxylic sugars like glycuronic acids were competitive inhibitors of sialic acid transport.
TextSentencer_T11 1292-1425 Sentence denotes Transstimulation of [14C] NeuAc uptake was observed when vesicles were preloaded either with unlabeled NeuAc or with glucuronic acid.
T11 1292-1425 Sentence denotes Transstimulation of [14C] NeuAc uptake was observed when vesicles were preloaded either with unlabeled NeuAc or with glucuronic acid.
TextSentencer_T12 1426-1564 Sentence denotes The data demonstrate that lysosomal membrane vesicles from rat liver are a suitable system for kinetic studies of solute transport events.
T12 1426-1564 Sentence denotes The data demonstrate that lysosomal membrane vesicles from rat liver are a suitable system for kinetic studies of solute transport events.
TextSentencer_T13 1565-1717 Sentence denotes The presence of a proton-driven carrier in the lysosomal membrane specific for sialic acid and other acidic sugars, including glucuronic acid, is shown.
T13 1565-1717 Sentence denotes The presence of a proton-driven carrier in the lysosomal membrane specific for sialic acid and other acidic sugars, including glucuronic acid, is shown.
TextSentencer_T14 1718-1874 Sentence denotes The possible physiological significance of these findings for the human lysosomal carrier and the patients with a sialic acid transport defect is discussed.
T14 1718-1874 Sentence denotes The possible physiological significance of these findings for the human lysosomal carrier and the patients with a sialic acid transport defect is discussed.