| Id |
Subject |
Object |
Predicate |
Lexical cue |
| TextSentencer_T1 |
0-128 |
Sentence |
denotes |
Internalization of a novel, huge lectin from Ibacus novemdentatus (slipper lobster) induces apoptosis of mammalian cancer cells. |
| T1 |
0-128 |
Sentence |
denotes |
Internalization of a novel, huge lectin from Ibacus novemdentatus (slipper lobster) induces apoptosis of mammalian cancer cells. |
| TextSentencer_T2 |
129-615 |
Sentence |
denotes |
An N-acetyl sugar-binding lectin (termed iNoL) displaying cytotoxic activity against human cancer cells was isolated from the slipper lobster Ibacus novemdentatus (family Scyllaridae). iNoL recognized monosaccharides containing N-acetyl group, and glycoproteins (e.g., BSM) containing oligosaccharides with N-acetyl sugar. iNoL was composed of five subunits (330, 260, 200, 140, and 30 kDa), which in turn consisted of 70-, 40-, and 30-kDa polypeptides held together by disulfide bonds. |
| T2 |
129-615 |
Sentence |
denotes |
An N-acetyl sugar-binding lectin (termed iNoL) displaying cytotoxic activity against human cancer cells was isolated from the slipper lobster Ibacus novemdentatus (family Scyllaridae). iNoL recognized monosaccharides containing N-acetyl group, and glycoproteins (e.g., BSM) containing oligosaccharides with N-acetyl sugar. iNoL was composed of five subunits (330, 260, 200, 140, and 30 kDa), which in turn consisted of 70-, 40-, and 30-kDa polypeptides held together by disulfide bonds. |
| TextSentencer_T3 |
616-985 |
Sentence |
denotes |
Electron microscopic observations and gel permeation chromatography indicated that iNoL was a huge (500-kDa) molecule and had a polygonal structure under physiological conditions. iNoL displayed cytotoxic (apoptotic) effects against human cancer cell lines MCF7 and T47D (breast), HeLa (ovarian), and Caco2 (colonic), through incorporation (internalization) into cells. |
| T3 |
616-985 |
Sentence |
denotes |
Electron microscopic observations and gel permeation chromatography indicated that iNoL was a huge (500-kDa) molecule and had a polygonal structure under physiological conditions. iNoL displayed cytotoxic (apoptotic) effects against human cancer cell lines MCF7 and T47D (breast), HeLa (ovarian), and Caco2 (colonic), through incorporation (internalization) into cells. |
| TextSentencer_T4 |
986-1042 |
Sentence |
denotes |
The lectin was transported into lysosomes via endosomes. |
| T4 |
986-1042 |
Sentence |
denotes |
The lectin was transported into lysosomes via endosomes. |
| TextSentencer_T5 |
1043-1162 |
Sentence |
denotes |
Its cytotoxic effect and incorporation into cells were inhibited by the co-presence of N-acetyl-D-mannosamine (ManNAc). |
| T5 |
1043-1162 |
Sentence |
denotes |
Its cytotoxic effect and incorporation into cells were inhibited by the co-presence of N-acetyl-D-mannosamine (ManNAc). |
| TextSentencer_T6 |
1163-1294 |
Sentence |
denotes |
Treatment of HeLa cells with iNoL resulted in DNA fragmentation and chromatin condensation, through activation of caspase-9 and -3. |
| T6 |
1163-1294 |
Sentence |
denotes |
Treatment of HeLa cells with iNoL resulted in DNA fragmentation and chromatin condensation, through activation of caspase-9 and -3. |
| TextSentencer_T7 |
1295-1458 |
Sentence |
denotes |
In summary, the novel crustacean lectin iNoL is incorporated into mammalian cancer cells through glycoconjugate interaction, and has cytotoxic (apoptotic) effects. |
| T7 |
1295-1458 |
Sentence |
denotes |
In summary, the novel crustacean lectin iNoL is incorporated into mammalian cancer cells through glycoconjugate interaction, and has cytotoxic (apoptotic) effects. |
