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PubMed:27496764 JSONTXT 60 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-104 Sentence denotes The structural investigation of glycosaminoglycan binding to CXCL12 displays distinct interaction sites.
T1 0-104 Sentence denotes The structural investigation of glycosaminoglycan binding to CXCL12 displays distinct interaction sites.
TextSentencer_T2 105-270 Sentence denotes The stromal cell-derived factor 1α (CXCL12) belongs to the CXC chemokine family and plays an important role in tissue regeneration and the recruitment of stem cells.
T2 105-270 Sentence denotes The stromal cell-derived factor 1α (CXCL12) belongs to the CXC chemokine family and plays an important role in tissue regeneration and the recruitment of stem cells.
TextSentencer_T3 271-394 Sentence denotes Here, a stable chemotactic gradient is essential that is formed by the interaction of CXCL12 with the extracellular matrix.
T3 271-394 Sentence denotes Here, a stable chemotactic gradient is essential that is formed by the interaction of CXCL12 with the extracellular matrix.
TextSentencer_T4 395-654 Sentence denotes Binding properties of CXCL12 to naturally occurring glycosaminoglycans (GAGs) as well as to the artificial highly sulfated hyaluronic acid (HA) are investigated by using a combination of NMR spectroscopy, molecular modeling and molecular dynamics simulations.
T4 395-654 Sentence denotes Binding properties of CXCL12 to naturally occurring glycosaminoglycans (GAGs) as well as to the artificial highly sulfated hyaluronic acid (HA) are investigated by using a combination of NMR spectroscopy, molecular modeling and molecular dynamics simulations.
TextSentencer_T5 655-765 Sentence denotes Our results demonstrate a preferred protein binding for the sulfated GAGs heparin (HE) and highly sulfated HA.
T5 655-765 Sentence denotes Our results demonstrate a preferred protein binding for the sulfated GAGs heparin (HE) and highly sulfated HA.
TextSentencer_T6 766-859 Sentence denotes Furthermore, we could demonstrate that the orientation of the sulfate is crucial for binding.
T6 766-859 Sentence denotes Furthermore, we could demonstrate that the orientation of the sulfate is crucial for binding.
TextSentencer_T7 860-998 Sentence denotes All sulfated GAGs interact with the CXCL12 GAG-binding motif (K24-H25-L26-K27-R41-K43-R47), where K27 and R41 represent the anchor points.
T7 860-998 Sentence denotes All sulfated GAGs interact with the CXCL12 GAG-binding motif (K24-H25-L26-K27-R41-K43-R47), where K27 and R41 represent the anchor points.
TextSentencer_T8 999-1250 Sentence denotes Furthermore, differences could be observed in the second interaction interface of CXCL12: both HE and highly sulfated HA interfere with the receptor-binding motif, while chondroitin sulfate binds different amino acids in close proximity to this motif.
T8 999-1250 Sentence denotes Furthermore, differences could be observed in the second interaction interface of CXCL12: both HE and highly sulfated HA interfere with the receptor-binding motif, while chondroitin sulfate binds different amino acids in close proximity to this motif.
TextSentencer_T9 1251-1423 Sentence denotes CXCL12 does not interact with HA, which was directly demonstrated by NMR spectroscopy and molecular modeling and explained by the lack of sulfate groups of the HA molecule.
T9 1251-1423 Sentence denotes CXCL12 does not interact with HA, which was directly demonstrated by NMR spectroscopy and molecular modeling and explained by the lack of sulfate groups of the HA molecule.