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PubMed:27371349 / 127-1492 JSONTXT 10 Projects

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Id Subject Object Predicate Lexical cue
T2 0-82 Sentence denotes Protein degradation by the proteasome generates functional intracellular peptides.
T2 0-82 Sentence denotes Protein degradation by the proteasome generates functional intracellular peptides.
T3 83-223 Sentence denotes Pep5, a peptide derived from Cyclin D2, induces cell death in tumor cell lines and reduces the volume of rat C6 glioblastoma tumors in vivo.
T3 83-223 Sentence denotes Pep5, a peptide derived from Cyclin D2, induces cell death in tumor cell lines and reduces the volume of rat C6 glioblastoma tumors in vivo.
T4 224-374 Sentence denotes Here, we chose the human MDA-MB-231 breast cancer cells to evaluate the mechanism of cell death induced by pep5 in different phases of the cell cycle.
T4 224-374 Sentence denotes Here, we chose the human MDA-MB-231 breast cancer cells to evaluate the mechanism of cell death induced by pep5 in different phases of the cell cycle.
T5 375-542 Sentence denotes Fluorescently labeled pep5, monitored by real time confocal microscopy, entered the MDA-MB-231 cells 3min after application and localized to the nucleus and cytoplasm.
T5 375-542 Sentence denotes Fluorescently labeled pep5, monitored by real time confocal microscopy, entered the MDA-MB-231 cells 3min after application and localized to the nucleus and cytoplasm.
T6 543-698 Sentence denotes Pep5-induced cell death was increased when the MDA-MB-231 cell population was arrested at the G1/S transition or in S phase compared to asynchronous cells.
T6 543-698 Sentence denotes Pep5-induced cell death was increased when the MDA-MB-231 cell population was arrested at the G1/S transition or in S phase compared to asynchronous cells.
T7 699-837 Sentence denotes Pep5 induced permanent extracellular signal-regulated kinase (ERK1/2) phosphorylation in MDA-MB-231 cells synchronized in G1/S or S phase.
T7 699-837 Sentence denotes Pep5 induced permanent extracellular signal-regulated kinase (ERK1/2) phosphorylation in MDA-MB-231 cells synchronized in G1/S or S phase.
T8 838-1027 Sentence denotes Affinity chromatography followed by mass spectrometry identified CLIC1 and Plectin as the only two proteins that interacted with pep5 in both asynchronous and synchronized MDA-MB-231 cells.
T8 838-1027 Sentence denotes Affinity chromatography followed by mass spectrometry identified CLIC1 and Plectin as the only two proteins that interacted with pep5 in both asynchronous and synchronized MDA-MB-231 cells.
T9 1028-1230 Sentence denotes These interactions could explain the long-lasting ERK1/2 phosphorylation and the cytoskeleton perturbations in the MDA-MB-231 cells, in which the stress fibers' integrity is affected by pep5 treatments.
T9 1028-1230 Sentence denotes These interactions could explain the long-lasting ERK1/2 phosphorylation and the cytoskeleton perturbations in the MDA-MB-231 cells, in which the stress fibers' integrity is affected by pep5 treatments.
T10 1231-1365 Sentence denotes These data suggest that pep5 has potential therapeutic properties for treating specific types of cancers, such as breast cancer cells.
T10 1231-1365 Sentence denotes These data suggest that pep5 has potential therapeutic properties for treating specific types of cancers, such as breast cancer cells.