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PubMed:27320813 JSONTXT 7 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-121 Sentence denotes Interplay between 15-lipoxygenase-1 and metastasis-associated antigen 1 in the metastatic potential of colorectal cancer.
T1 0-121 Sentence denotes Interplay between 15-lipoxygenase-1 and metastasis-associated antigen 1 in the metastatic potential of colorectal cancer.
TextSentencer_T2 122-133 Sentence denotes OBJECTIVES:
T2 122-133 Sentence denotes OBJECTIVES:
TextSentencer_T3 134-304 Sentence denotes Metastasis-associated antigen 1 (MTA1) is implicated in metastasis while 15-lipoxygenase-1 (15-LOX-1) reduces cell motility, when re-expressed in colorectal cancer (CRC).
T3 134-304 Sentence denotes Metastasis-associated antigen 1 (MTA1) is implicated in metastasis while 15-lipoxygenase-1 (15-LOX-1) reduces cell motility, when re-expressed in colorectal cancer (CRC).
TextSentencer_T4 305-396 Sentence denotes We aimed to understand any potential interplay between MTA1 and 15-LOX-1 in CRC metastasis.
T4 305-396 Sentence denotes We aimed to understand any potential interplay between MTA1 and 15-LOX-1 in CRC metastasis.
TextSentencer_T5 397-562 Sentence denotes MATERIALS AND METHODS: ALOX15 and MTA1 expression in tumour and normal samples were analysed from TCGA RNA-seq data, microarray data sets and a human CRC cDNA array.
T5 397-562 Sentence denotes MATERIALS AND METHODS: ALOX15 and MTA1 expression in tumour and normal samples were analysed from TCGA RNA-seq data, microarray data sets and a human CRC cDNA array.
TextSentencer_T6 563-797 Sentence denotes Western blots, chromatin immunoprecipitation (ChIP), luciferase assays and electrophoretic mobility shift assays (EMSA) were carried out in HT-29 and LoVo cells re-expressing 15-LOX-1 to determine NF- κB activity at the MTA1 promoter.
T6 563-797 Sentence denotes Western blots, chromatin immunoprecipitation (ChIP), luciferase assays and electrophoretic mobility shift assays (EMSA) were carried out in HT-29 and LoVo cells re-expressing 15-LOX-1 to determine NF- κB activity at the MTA1 promoter.
TextSentencer_T7 798-937 Sentence denotes Functional assays in cells ectopically expressing either 15-LOX-1, MTA-1 or both, were carried out to determine adhesion and cell motility.
T7 798-937 Sentence denotes Functional assays in cells ectopically expressing either 15-LOX-1, MTA-1 or both, were carried out to determine adhesion and cell motility.
TextSentencer_T8 938-946 Sentence denotes RESULTS:
T8 938-946 Sentence denotes RESULTS:
TextSentencer_T9 947-1106 Sentence denotes Significantly higher expression of MTA1 was observed in tumours compared to normal tissues; MTA1 overexpression resulted in reduced adhesion in CRC cell lines.
T9 947-1106 Sentence denotes Significantly higher expression of MTA1 was observed in tumours compared to normal tissues; MTA1 overexpression resulted in reduced adhesion in CRC cell lines.
TextSentencer_T10 1107-1362 Sentence denotes Re-expression of 15-LOX-1 in the CRC cell lines reduced expression of endogenous MTA1, corroborated by negative correlation between the two genes in two independent human CRC microarray data sets, with greater significance in specific subsets of patients.
T10 1107-1362 Sentence denotes Re-expression of 15-LOX-1 in the CRC cell lines reduced expression of endogenous MTA1, corroborated by negative correlation between the two genes in two independent human CRC microarray data sets, with greater significance in specific subsets of patients.
TextSentencer_T11 1363-1490 Sentence denotes DNA binding and transcriptional activity of NF-κB at the MTA1 promoter was significantly lower in cells re-expressing 15-LOX-1.
T11 1363-1490 Sentence denotes DNA binding and transcriptional activity of NF-κB at the MTA1 promoter was significantly lower in cells re-expressing 15-LOX-1.
TextSentencer_T12 1491-1657 Sentence denotes Functionally, the same cells had reduced motility, which was rescued when they overexpressed MTA1, and further corroborated by expressions of E-cadherin and vimentin.
T12 1491-1657 Sentence denotes Functionally, the same cells had reduced motility, which was rescued when they overexpressed MTA1, and further corroborated by expressions of E-cadherin and vimentin.
TextSentencer_T13 1658-1670 Sentence denotes CONCLUSIONS:
T13 1658-1670 Sentence denotes CONCLUSIONS:
TextSentencer_T14 1671-1752 Sentence denotes Expression of MTA1 and 15-LOX-1 negatively correlated in specific subsets of CRC.
T14 1671-1752 Sentence denotes Expression of MTA1 and 15-LOX-1 negatively correlated in specific subsets of CRC.
TextSentencer_T15 1753-1853 Sentence denotes Mechanistically, this is at least in part through reduced recruitment of NF-κB to the MTA1 promoter.
T15 1753-1853 Sentence denotes Mechanistically, this is at least in part through reduced recruitment of NF-κB to the MTA1 promoter.