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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-90 Sentence denotes Modulating the endometrial epithelial proteome and secretome in preparation for pregnancy:
T1 0-90 Sentence denotes Modulating the endometrial epithelial proteome and secretome in preparation for pregnancy:
TextSentencer_T2 91-142 Sentence denotes The role of ovarian steroid and pregnancy hormones.
T2 91-142 Sentence denotes The role of ovarian steroid and pregnancy hormones.
TextSentencer_T3 143-154 Sentence denotes UNLABELLED:
T3 143-154 Sentence denotes UNLABELLED:
TextSentencer_T4 155-301 Sentence denotes Dialogue between an appropriately developed embryo and hormonally-primed endometrium is essential to achieve implantation and establish pregnancy.
T4 155-301 Sentence denotes Dialogue between an appropriately developed embryo and hormonally-primed endometrium is essential to achieve implantation and establish pregnancy.
TextSentencer_T5 302-440 Sentence denotes Importantly, the point-of-first-contact between the embryo and the maternal endometrium occurs at the endometrial luminal epithelium (LE).
T5 302-440 Sentence denotes Importantly, the point-of-first-contact between the embryo and the maternal endometrium occurs at the endometrial luminal epithelium (LE).
TextSentencer_T6 441-537 Sentence denotes Implantation events occur within the uterine cavity microenvironment regulated by local factors.
T6 441-537 Sentence denotes Implantation events occur within the uterine cavity microenvironment regulated by local factors.
TextSentencer_T7 538-752 Sentence denotes Defects in embryo-endometrial communication likely underlie unexplained infertility; enhanced knowledge of this communication, specifically at initial maternal-fetal contact may reveal targets to improve fertility.
T7 538-752 Sentence denotes Defects in embryo-endometrial communication likely underlie unexplained infertility; enhanced knowledge of this communication, specifically at initial maternal-fetal contact may reveal targets to improve fertility.
TextSentencer_T8 753-1148 Sentence denotes Using a human endometrial luminal-epithelial (LE) cell line (ECC1), this targeted proteomic study reveals unique protein changes in both cellular (98% unique identifications) and secreted (96% unique identifications) proteins in the transition to the progesterone-dominated secretory (receptive) phase and subsequently to pregnancy, mediated by embryo-derived human chorionic gonadotropin (hCG).
T8 753-1148 Sentence denotes Using a human endometrial luminal-epithelial (LE) cell line (ECC1), this targeted proteomic study reveals unique protein changes in both cellular (98% unique identifications) and secreted (96% unique identifications) proteins in the transition to the progesterone-dominated secretory (receptive) phase and subsequently to pregnancy, mediated by embryo-derived human chorionic gonadotropin (hCG).
TextSentencer_T9 1149-1278 Sentence denotes This analysis identified 157 progesterone-regulated cellular proteins, with further 193 significantly altered in response to hCG.
T9 1149-1278 Sentence denotes This analysis identified 157 progesterone-regulated cellular proteins, with further 193 significantly altered in response to hCG.
TextSentencer_T10 1279-1404 Sentence denotes Cellular changes were associated with metabolism, basement membrane and cell connectivity, proliferation and differentiation.
T10 1279-1404 Sentence denotes Cellular changes were associated with metabolism, basement membrane and cell connectivity, proliferation and differentiation.
TextSentencer_T11 1405-1681 Sentence denotes Secretome analysis identified 1059 proteins; 123 significantly altered by progesterone, and 43 proteins altered by hCG, including proteins associated with cellular adhesion, extracellular-matrix organization, developmental growth, growth factor regulation, and cell signaling.
T11 1405-1681 Sentence denotes Secretome analysis identified 1059 proteins; 123 significantly altered by progesterone, and 43 proteins altered by hCG, including proteins associated with cellular adhesion, extracellular-matrix organization, developmental growth, growth factor regulation, and cell signaling.
TextSentencer_T12 1682-1842 Sentence denotes Collectively, our findings reveal dynamic intracellular and secreted protein changes in the endometrium that may modulate successful establishment of pregnancy.
T12 1682-1842 Sentence denotes Collectively, our findings reveal dynamic intracellular and secreted protein changes in the endometrium that may modulate successful establishment of pregnancy.
TextSentencer_T13 1843-1867 Sentence denotes BIOLOGICAL SIGNIFICANCE:
T13 1843-1867 Sentence denotes BIOLOGICAL SIGNIFICANCE:
TextSentencer_T14 1868-2175 Sentence denotes This study provides unique insights into the developmental biology of embryo implantation using targeted proteomics by identifying endometrial epithelial cellular and secreted protein changes in response to ovarian steroid hormones and pregnancy hormones that are essential for receptivity and implantation.
T14 1868-2175 Sentence denotes This study provides unique insights into the developmental biology of embryo implantation using targeted proteomics by identifying endometrial epithelial cellular and secreted protein changes in response to ovarian steroid hormones and pregnancy hormones that are essential for receptivity and implantation.