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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-145 Sentence denotes Proteome analysis reveals translational inhibition of Caenorhabditis elegans enhances susceptibility to Pseudomonas aeruginosa PAO1 pathogenesis.
T1 0-145 Sentence denotes Proteome analysis reveals translational inhibition of Caenorhabditis elegans enhances susceptibility to Pseudomonas aeruginosa PAO1 pathogenesis.
TextSentencer_T2 146-157 Sentence denotes UNLABELLED:
T2 146-157 Sentence denotes UNLABELLED:
TextSentencer_T3 158-279 Sentence denotes Caenorhabditis elegans-Pseudomonas aeruginosa infection model is commonly used for pathogenesis studies over the decades.
T3 158-279 Sentence denotes Caenorhabditis elegans-Pseudomonas aeruginosa infection model is commonly used for pathogenesis studies over the decades.
TextSentencer_T4 280-497 Sentence denotes In the present study, upon exposure to the Pseudomonas aeruginosa PAO1, the 2D-PAGE was performed to examine the total proteins differences of C. elegans during the PAO1 infection at different time durations (12-48h).
T4 280-497 Sentence denotes In the present study, upon exposure to the Pseudomonas aeruginosa PAO1, the 2D-PAGE was performed to examine the total proteins differences of C. elegans during the PAO1 infection at different time durations (12-48h).
TextSentencer_T5 498-637 Sentence denotes Also, the 2D-DIGE using the cyanine dyes were performed (48h) to identify the differentially regulated proteins against the PAO1 infection.
T5 498-637 Sentence denotes Also, the 2D-DIGE using the cyanine dyes were performed (48h) to identify the differentially regulated proteins against the PAO1 infection.
TextSentencer_T6 638-739 Sentence denotes Among the 19 short-listed proteins, 5 proteins were down-regulated and 14 proteins were up-regulated.
T6 638-739 Sentence denotes Among the 19 short-listed proteins, 5 proteins were down-regulated and 14 proteins were up-regulated.
TextSentencer_T7 740-890 Sentence denotes Eukaryotic elongation factor-2 (EEF-2), a GTP binding protein involves in protein elongation process was down regulated during the pathogen infection.
T7 740-890 Sentence denotes Eukaryotic elongation factor-2 (EEF-2), a GTP binding protein involves in protein elongation process was down regulated during the pathogen infection.
TextSentencer_T8 891-1124 Sentence denotes The 2D-PAGE analysis and MS data for the 12 and 24h infections identified the NDK-1 and other essential protein includes, ACS-18, ACT-1, GPD-3, GDH-1 and LBP-6 which are involved in important cellular homeostasis were down regulated.
T8 891-1124 Sentence denotes The 2D-PAGE analysis and MS data for the 12 and 24h infections identified the NDK-1 and other essential protein includes, ACS-18, ACT-1, GPD-3, GDH-1 and LBP-6 which are involved in important cellular homeostasis were down regulated.
TextSentencer_T9 1125-1489 Sentence denotes Validation studies using qPCR analysis for eef-2 and other selected genes, western blot analysis for EEF-2 and effect of host translational inhibition studies using Cycloheximide during PAO1 infection suggests that P. aeruginosa systematically restrains the function of host by arresting the expression of EEF-2 and thereby inhibiting protein translational events.
T9 1125-1489 Sentence denotes Validation studies using qPCR analysis for eef-2 and other selected genes, western blot analysis for EEF-2 and effect of host translational inhibition studies using Cycloheximide during PAO1 infection suggests that P. aeruginosa systematically restrains the function of host by arresting the expression of EEF-2 and thereby inhibiting protein translational events.
TextSentencer_T10 1490-1633 Sentence denotes Further, in silico analysis revealed the Exotoxin A could directly bind with the host EEF-2 and NDK-1 during the C. elegans- PAO1 interactions.
T10 1490-1633 Sentence denotes Further, in silico analysis revealed the Exotoxin A could directly bind with the host EEF-2 and NDK-1 during the C. elegans- PAO1 interactions.
TextSentencer_T11 1634-1658 Sentence denotes BIOLOGICAL SIGNIFICANCE:
T11 1634-1658 Sentence denotes BIOLOGICAL SIGNIFICANCE:
TextSentencer_T12 1659-1769 Sentence denotes Model system, C. elegans facilitates the identification of virulence mechanisms during bacterial pathogenesis.
T12 1659-1769 Sentence denotes Model system, C. elegans facilitates the identification of virulence mechanisms during bacterial pathogenesis.
TextSentencer_T13 1770-2006 Sentence denotes Upon infection by the fungal and bacterial pathogens, the C. elegans system induces an array of transcriptional responses, including differential expression of effector/modulator genes that provide safeguard and fight against infection.
T13 1770-2006 Sentence denotes Upon infection by the fungal and bacterial pathogens, the C. elegans system induces an array of transcriptional responses, including differential expression of effector/modulator genes that provide safeguard and fight against infection.
TextSentencer_T14 2007-2105 Sentence denotes However, the in-depth knowledge of host response by the pathogen at protein level remains unclear.
T14 2007-2105 Sentence denotes However, the in-depth knowledge of host response by the pathogen at protein level remains unclear.
TextSentencer_T15 2106-2269 Sentence denotes Much of the studies were carried out only at the transcripts level and scarce reports are available at the protein level for the host-pathogen interaction studies.
T15 2106-2269 Sentence denotes Much of the studies were carried out only at the transcripts level and scarce reports are available at the protein level for the host-pathogen interaction studies.
TextSentencer_T16 2270-2570 Sentence denotes In order to provide few interesting clues at the protein level, the nematode, C. elegans was infected with the human pathogen P. aeruginosa and the response(s) of host was investigated at the protein level by 2D-DIGE analysis and further validation studies using qPCR and western blotting techniques.
T16 2270-2570 Sentence denotes In order to provide few interesting clues at the protein level, the nematode, C. elegans was infected with the human pathogen P. aeruginosa and the response(s) of host was investigated at the protein level by 2D-DIGE analysis and further validation studies using qPCR and western blotting techniques.
TextSentencer_T17 2571-2726 Sentence denotes Our differential proteomics data suggest that translational inhibition as one of the patterns of pathogenesis in C. elegans during P. aeruginosa infection.
T17 2571-2726 Sentence denotes Our differential proteomics data suggest that translational inhibition as one of the patterns of pathogenesis in C. elegans during P. aeruginosa infection.
TextSentencer_T18 2727-2998 Sentence denotes Since many of the effectors identified through C. elegans are conserved in other systems including human, our data pave the way for understanding important regulatory pathways involved during bacterial pathogenesis that can be translated into higher eukaryotic organisms.
T18 2727-2998 Sentence denotes Since many of the effectors identified through C. elegans are conserved in other systems including human, our data pave the way for understanding important regulatory pathways involved during bacterial pathogenesis that can be translated into higher eukaryotic organisms.